caa a22 4500 445336544 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1612-8 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1612-8 Mucinous Rectal Cancer: Effectiveness of Preoperative Chemoradiotherapy and Prognosis [Elektronische Daten] [Ui Shin, Chang Yu, Jong Kim, Tae Kim, Seok-Byoung Lim, Sang Yoon, Yong Yoon, Chan Kim, Jin Kim] Background: This study investigated the effects of preoperative chemoradiotherapy (PCRT) and the prognoses of patients with mucinous rectal cancer compared with those with nonmucinous cancer. Methods: We retrospectively reviewed the medical records of 368 patients who underwent curative resection after PCRT, between 2000 and 2006, for midrectal to lower-rectal adenocarcinoma. Mucinous cancers were present in 23 patients (6.3%) and nonmucinous cancers in 345. In each patient, clinical stage before chemoradiotherapy was compared with pathologic stage to evaluate the extent of downstaging. Survival and multivariate analyses were performed using clinicopathologic variables. The median follow-up period was 42months (range, 4-105months). Results: There was no difference in clinical stage between the groups. Although 58 patients (16.8%) in the nonmucinous group achieved pathologic complete responses (pCR), no mucinous group patient showed such a response. T-downstaging was more frequently observed in the nonmucinous than in the mucinous group (189 vs 7 [54.9% vs 30.4%], P=.03), but N-downstaging was similar in the 2 groups. The 5-year overall survival rate (OS) was significantly lower in the mucinous than in the nonmucinous group (64.8% vs 79.8%, P=.049). Multivariate analysis revealed that mucinous histotype was an independent (negative) prognostic factor for survival (hazard ratio, 2.36; 95% confidence interval, 1.05-5.3; P=.04). Conclusions: Patients with mucinous rectal cancer experienced a lower rate of T-downstaging after PCRT and had a poorer prognosis than did patients with nonmucinous cancer. Society of Surgical Oncology, 2011 Shin Ui Department of Surgery, Korea Institute of Radiological & Medical Sciences, Korea Cancer Center Hospital, Seoul, Korea aut Yu Chang Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Kim Jong Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Kim Tae Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Lim Seok-Byoung Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Yoon Sang Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Yoon Yong Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Kim Chan Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Kim Jin Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2232-2239 1068-9265 18:8<2232 2011 18 10434 https://doi.org/10.1245/s10434-011-1612-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1612-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin Ui Department of Surgery, Korea Institute of Radiological & Medical Sciences, Korea Cancer Center Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Yu Chang Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jong Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Tae Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Lim Seok-Byoung Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Yoon Sang Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Yoon Yong Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Chan Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jin Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2232-2239 1068-9265 18:8<2232 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer