caa a22 4500 445336579 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1245/s10434-011-1577-7 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1577-7 Clinical Significance of Alpha-Fetoprotein mRNA in Peripheral Blood in Liver Resection for Hepatocellular Carcinoma [Elektronische Daten] [Shigeru Marubashi, Hiroaki Nagano, Hiroshi Wada, Shogo Kobayashi, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori] Purpose: Detection of AFP mRNA in peripheral blood is considered a useful predictor of HCC recurrence after resection. However, its interpretation and clinical significance remains to be determined. This study was designed to evaluate the clinical significance of detecting AFP mRNA positive cells in peripheral blood. Methods: A total of 153 patients without macroscopic vascular invasion, who underwent liver resection, were prospectively enrolled in this study. The pattern of HCC recurrence was confirmed by image studies and divided into four types: (1) no recurrence (control group, n=68); (2) intrahepatic single recurrence (SR group, n=28); (3) intrahepatic multiple recurrences (MR group, n=38); and (4) extrahepatic HCC recurrence (EX group, n=19). Results: HCC recurrence was identified in 85 (55.6%) patients during a follow-up of 8.6±6.7 (range, 0.7-36) months. Multivariate analysis identified preoperative AFP mRNA (HR=2.54; P=0.006) as an independent risk factor for HCC recurrence. Preoperative AFP mRNA expression was a significant predictor of HCC recurrence in the MR/EX group (P=0.029) but not in the SR group (P=0.467). Conclusions: Detection of AFP mRNA expression in peripheral blood before surgery for HCC is a useful predictor of multiple or extrahepatic HCC recurrences. Society of Surgical Oncology, 2011 Marubashi Shigeru Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Nagano Hiroaki Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Wada Hiroshi Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Kobayashi Shogo Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Eguchi Hidetoshi Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Takeda Yutaka Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Tanemura Masahiro Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Umeshita Koji Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Doki Yuichiro Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Mori Masaki Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2200-2209 1068-9265 18:8<2200 2011 18 10434 https://doi.org/10.1245/s10434-011-1577-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1577-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marubashi Shigeru Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Nagano Hiroaki Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Wada Hiroshi Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kobayashi Shogo Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Eguchi Hidetoshi Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takeda Yutaka Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Tanemura Masahiro Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Umeshita Koji Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Doki Yuichiro Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Mori Masaki Department of Surgery, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/8(2011-08-01), 2200-2209 1068-9265 18:8<2200 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer