caa a22 4500 445336609 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1441-1 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1441-1 Ductal Carcinoma In Situ of the Breast: Influence of Age on Diagnostic, Therapeutic, and Prognostic Features. Retrospective Study of 812 Patients [Elektronische Daten] [Christine Tunon-de-Lara, Gwenaëlle André, Gaétan MacGrogan, Jean-Marie Dilhuydy, Jean-Emmanuel Bussières, Marc Debled, Louis Mauriac, Véronique Brouste, Isabelle de Mascarel, Antoine Avril] Background: The objective of this retrospective study was to identify prognostic, diagnostic, and therapeutic disparities between younger (≤40years) and older (>40years) women with ductal carcinoma in situ (DCIS) of the breast. Methods: From 1971 to 2001, all patients treated for DCIS at Institut Bergonié were included in our analyses. Follow-up data was collected over 10years. We used univariate and multivariate analyses to investigate patient-, disease-, and treatment-related factors predictive of diagnostic, histological, therapeutic, and prognostic DCIS criteria. Results: A total of 812 patients were eligible including 731 women aged >40years and 81 women ≤40years. Younger women with DCIS were more likely to receive a mastectomy and less likely to receive radiotherapy. Young age and initial surgical treatment (lumpectomy and especially nonfree margins) were revealed as predictive of recurrence in multivariate analyses. Conclusions: Young age represents a recurrence risk independent of histological and clinical characteristics of the tumor. Initial treatment, especially for nonfree margins, is also a predictive factor. Appropriate initial surgery with particularly wide margins appears essential for the treatment of young women with DCIS. Society of Surgical Oncology, 2010 Tunon-de-Lara Christine Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut André Gwenaëlle Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut MacGrogan Gaétan Department of Pathology, Institut Bergonié, Bordeaux Cedex, France aut Dilhuydy Jean-Marie Department of Radiotherapy, Institut Bergonié, Bordeaux Cedex, France aut Bussières Jean-Emmanuel Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut Debled Marc Department of Medical Oncology, Institut Bergonié, Bordeaux Cedex, France aut Mauriac Louis Department of Medical Oncology, Institut Bergonié, Bordeaux Cedex, France aut Brouste Véronique Unité de Recherche et d'Epidémiologie Cliniques, Institut Bergonié, Bordeaux Cedex, France aut de Mascarel Isabelle Department of Pathology, Institut Bergonié, Bordeaux Cedex, France aut Avril Antoine Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1372-1379 1068-9265 18:5<1372 2011 18 10434 https://doi.org/10.1245/s10434-010-1441-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1441-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tunon-de-Lara Christine Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- André Gwenaëlle Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- MacGrogan Gaétan Department of Pathology, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Dilhuydy Jean-Marie Department of Radiotherapy, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Bussières Jean-Emmanuel Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Debled Marc Department of Medical Oncology, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Mauriac Louis Department of Medical Oncology, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Brouste Véronique Unité de Recherche et d'Epidémiologie Cliniques, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- de Mascarel Isabelle Department of Pathology, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Avril Antoine Department of Surgery, Institut Bergonié, Bordeaux Cedex, France aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1372-1379 1068-9265 18:5<1372 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer