caa a22 4500 445336633 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1417-1 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1417-1 Durability of Focused Minimally Invasive Parathyroidectomy in Young Patients with Sporadic Primary Hyperparathyroidism [Elektronische Daten] [Jennifer Oucharek, Christine O'Neill, James Suliburk, Mark Sywak, Leigh Delbridge, Stan Sidhu] Background: Historically, multigland hyperplasia was believed to be the predominant cause of primary hyperparathyroidism (PHPT) in young patients, and hence a relative contraindication for minimally invasive parathyroidectomy. Recent studies, however, demonstrate that the most common aetiology across all age groups is a solitary functioning adenoma. The aim of this study was to compare long-term outcomes in young patients (≤45years), especially those under 30years of age, with their older counterparts (>45years) following focused minimally invasive parathyroidectomy (FMIP). Materials and Methods: Patients ≤45years who underwent FMIP between January 1999 and December 2007 were identified from an endocrine surgery database and compared with a matched control group of patients >45years old also undergoing FMIP within that time period. The patients' most recent calcium levels (≥6months postoperatively) were examined to establish recurrence rates. Recurrence was defined as an elevation of serum calcium more than 6months after surgery following initial postsurgical normocalcemia. Results: A total of 117 patients ≤45years and 160 patients >45years who underwent FMIP were examined. Follow-up calcium levels were available for 72% of patients. The median length of follow-up was 46months. No recurrences were identified in both the younger and older cohort of patients; therefore, no statistically significant difference in rates of recurrence could be determined between age groups. Conclusion: Recurrence of PHPT following FMIP is rare with no evidence of a higher incidence in younger patients. FMIP can be safely offered to young patients as a long-term durable treatment option. Society of Surgical Oncology, 2010 Oucharek Jennifer University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut O'Neill Christine University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut Suliburk James University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut Sywak Mark University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut Delbridge Leigh University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut Sidhu Stan University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1290-1292 1068-9265 18:5<1290 2011 18 10434 https://doi.org/10.1245/s10434-010-1417-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1417-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oucharek Jennifer University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut NATIONALLICENCE 700 1- O'Neill Christine University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut NATIONALLICENCE 700 1- Suliburk James University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut NATIONALLICENCE 700 1- Sywak Mark University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut NATIONALLICENCE 700 1- Delbridge Leigh University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut NATIONALLICENCE 700 1- Sidhu Stan University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, NSW, Australia aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1290-1292 1068-9265 18:5<1290 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer