caa a22 4500 445336641 CHVBK 20180317142757.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1420-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1420-6 Impact of Routine Cavity Shave Margins on Breast Cancer Re-excision Rates [Elektronische Daten] [Anne Kobbermann, Alison Unzeitig, Xian-Jin Xie, Jingsheng Yan, David Euhus, Yan Peng, Venetia Sarode, Amy Moldrem, A. Marilyn Leitch, Valerie Andrews, Carrie Stallings, Roshni Rao] Purpose: Breast-conserving therapy (BCT) is an accepted method of treating early breast cancer. We hypothesized that routine excision of additional cavity shave margins (CSM) at time of initial partial mastectomy reduces the need for additional surgery. Methods: A single-institution retrospective review was performed of women, 18years or older, with a new diagnosis of breast cancer who underwent partial mastectomy between 1 January 2004 and 1 October 2009. Five hundred thirty-three charts were reviewed. Of those, 69 patients underwent CSM at time of initial operation. These 69 patients were matched with patients who had undergone partial mastectomy without CSM by tumor size, presence of extensive intraductal component, and primary histology. Results: The two groups were well matched for age, nuclear grade, associated lymphovascular invasion (LVI), receptor status, and multifocality. We found that 31.9% (44/138) required return to the operating room (OR) for re-excision of margins. Rate of return to the OR was 21.7% (15/69) in the CSM group and 42.0% (29/69) in the matched group (p=0.011). Multivariate analysis found factors significantly associated with need for additional operation included lack of CSM (odds ratio 9.2, 95% CI 2.8-30.5, p=0.0003), larger extent of intraductal component (odds ratio 7.0, 95% CI 1.8-27.0, p=0.005), and lack of directed re-excision (odds ratio 6.4, 95% CI 1.7-25.1, p=0.007). Conclusions: CSM at time of initial partial mastectomy decreases rate of re-excision by as much as ninefold. CSM should be considered at time of initial operation to reduce the need for subsequent reoperation. Society of Surgical Oncology, 2010 Kobbermann Anne Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Unzeitig Alison Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Xie Xian-Jin Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Yan Jingsheng Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Euhus David Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Peng Yan Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Sarode Venetia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Moldrem Amy Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Marilyn Leitch A. Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Andrews Valerie Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Stallings Carrie Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Rao Roshni Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1349-1355 1068-9265 18:5<1349 2011 18 10434 https://doi.org/10.1245/s10434-010-1420-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1420-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kobbermann Anne Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Unzeitig Alison Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Xie Xian-Jin Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Yan Jingsheng Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Euhus David Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Peng Yan Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Sarode Venetia Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Moldrem Amy Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Marilyn Leitch A. Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Andrews Valerie Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Stallings Carrie Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 700 1- Rao Roshni Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1349-1355 1068-9265 18:5<1349 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer