caa a22 4500 445336668 CHVBK 20180317142758.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1454-9 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1454-9 Lower Uterine Segment Involvement is Associated with Poor Outcomes in Early-Stage Endometrioid Endometrial Carcinoma [Elektronische Daten] [Nora Kizer, Feng Gao, Saketh Guntupalli, Premal Thaker, Matthew Powell, Paul Goodfellow, David Mutch, Israel Zighelboim] Background: The clinicopathologic significance of lower uterine segment involvement (LUSI) in endometrial cancer patients remains unclear. Although LUSI has been reported to be a prognostic indicator, literature is limited. Methods: We studied 481 surgically staged endometrioid endometrial cancers with disease confined to the uterus (FIGO 1988 stage I or II). Primary outcomes were overall survival (OS) and disease-free survival (DFS). The relationships between LUSI and OS and DFS were assessed using the Kaplan-Meier method and Cox proportional hazard models. The t test or Fisher exact test was used for evaluating relationships between variables of interest. Results: LUSI was present in 223 cases (46.4%), and was associated with both decreased disease free survival (P=0.02) and overall survival (P=0.01) in univariate analysis. Multivariate analysis confirmed the association between LUSI and increased risk for recurrence [hazard ratio (HR) 2.27; 95% confidence interval (95% CI) 1.09-4.7; P=0.03] and increased mortality (HR 1.76; 95% CI 1.12-2.78; P=0.01). Conclusions: LUSI in patients with early-stage endometrioid endometrial cancer is associated with decreased survival. Society of Surgical Oncology, 2010 Kizer Nora Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Gao Feng Division of Biostatistics, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Guntupalli Saketh Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Thaker Premal Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Powell Matthew Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Goodfellow Paul Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Mutch David Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Zighelboim Israel Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1419-1424 1068-9265 18:5<1419 2011 18 10434 https://doi.org/10.1245/s10434-010-1454-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1454-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kizer Nora Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Gao Feng Division of Biostatistics, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Guntupalli Saketh Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Thaker Premal Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Powell Matthew Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Goodfellow Paul Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Mutch David Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Zighelboim Israel Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1419-1424 1068-9265 18:5<1419 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer