caa a22 4500 445336676 CHVBK 20180317142758.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1469-2 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1469-2 Characteristics of Primary Papillary Thyroid Carcinoma with False-Negative Findings on Initial 18F-FDG PET/CT [Elektronische Daten] [Jin Choi, Young Yoon, Yeo Yoon, Seong Kim, Bon Koo] Background: We often observe that uptake of tracer is not detected in the primary cancer focus in patients with histologically proven papillary thyroid carcinoma (PTC) on preoperative 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). Therefore, we analyzed the clinical and pathologic variables affecting false-negative findings in primary tumors on preoperative 18F-FDG PET/CT. Methods: We retrospectively reviewed the medical records of 115 consecutive patients who underwent 18F-FDG PET/CT for initial evaluation and were diagnosed with PTC by postoperative permanent biopsy. The clinical and pathologic characteristics that influence the 18F-FDG PET/CT findings in these patients were analyzed with respect to the following variables: age, gender, tumor size, multifocality of the primary tumor, perithyroidal invasion, lymphovascular or capsular invasion, and central lymph node metastasis-based final pathology. Results: Twenty-six (22.6%) patients had false-negative 18F-FDG PET/CT findings. In patients with negative 18F-FDG PET/CT findings, tumor size, and perithyroidal and lymphovascular invasion were significantly less than in patients with positive 18F-FDG PET/CT findings. Tumors >1cm in size were correlated with 18F-FDG PET/CT positivity. On multivariate analysis, perithyroidal invasion (P=0.026, odds ratio=7.714) and lymphovascular invasion (P=0.036, odds ratio=3.500) were independent factors for 18F-FDG PET/CT positivity. However, there were no significant differences between 18F-FDG PET/CT positivity and age, gender, capsular invasion, and central lymph node metastasis based on final pathology. Conclusions: Tumor size and perithyroidal and lymphovascular invasion of papillary carcinoma can influence 18F-FDG PET/CT findings. Absence of perithyroidal and lymphovascular invasion were independent variables for false-negative findings on initial 18F-FDG PET/CT in patients with PTC. Society of Surgical Oncology, 2010 Choi Jin Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut Yoon Young Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut Yoon Yeo Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut Kim Seong Department of Nuclear Medicine, Chungnam National University College of Medicine, Daejeon, Korea aut Koo Bon Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1306-1311 1068-9265 18:5<1306 2011 18 10434 https://doi.org/10.1245/s10434-010-1469-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1469-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choi Jin Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut NATIONALLICENCE 700 1- Yoon Young Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut NATIONALLICENCE 700 1- Yoon Yeo Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut NATIONALLICENCE 700 1- Kim Seong Department of Nuclear Medicine, Chungnam National University College of Medicine, Daejeon, Korea aut NATIONALLICENCE 700 1- Koo Bon Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University College of Medicine, School of Medicine, Daejeon, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1306-1311 1068-9265 18:5<1306 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer