caa a22 4500 445336714 CHVBK 20180317142758.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1483-4 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1483-4 The Association of Caveolin-1 Genotypes with Oral Cancer Susceptibility in Taiwan [Elektronische Daten] [Da-Tian Bau, Ming Tsai, Yung-An Tsou, Chung-Hsing Wang, Chia-Wen Tsai, Shung-Shung Sun, Chun-Hung Hua, Song-Kun Shyue, Ru-Yin Tsai] Background: Caveolin-1, which has been proposed as a candidate tumor suppressor, plays a regulatory role in several signaling pathways. The aim of this study was to evaluate the association between oral cancer susceptibility and Cav-1 genotypes. In this hospital-based case-control study, the association of Cav-1 polymorphisms with oral cancer risk in a central Taiwanese population was investigated. Methods: Six hundred patients with oral cancer and 620 age- and sex-matched healthy control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism. Results: There were significant differences between oral cancer and control groups in the distributions of their genotypes (P=1.7×10−18 and 2.6×10−4) and allelic frequencies (P=3.3×10−19 and 9.5×10−6) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for the combined genotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.72-fold (95% confidence interval=0.52-0.99) decreased risk of oral cancer compared to those with GG/TT, while those of any other combinations were of increased risk. The presence of metastasis was also correlated to both Cav-1 G14713A AA and Cav-1 T29107A TT genotypes. Conclusions: Cav-1 is involved in oral cancer, the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky combined genotype for the development of oral cancer and may be novel risk markers for early detection and prediction of distant metastasis. Society of Surgical Oncology, 2011 Bau Da-Tian Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Tsai Ming Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Tsou Yung-An Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Wang Chung-Hsing Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Tsai Chia-Wen Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Sun Shung-Shung Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Hua Chun-Hung Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Shyue Song-Kun Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan aut Tsai Ru-Yin Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1431-1438 1068-9265 18:5<1431 2011 18 10434 https://doi.org/10.1245/s10434-010-1483-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1483-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bau Da-Tian Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Tsai Ming Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Tsou Yung-An Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Wang Chung-Hsing Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Tsai Chia-Wen Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Sun Shung-Shung Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Hua Chun-Hung Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Shyue Song-Kun Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan aut NATIONALLICENCE 700 1- Tsai Ru-Yin Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1431-1438 1068-9265 18:5<1431 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer