caa a22 4500 445336781 CHVBK 20180317142758.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1423-3 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1423-3 Sequential Transcatheter Arterial Chemoembolization and Portal Vein Embolization versus Portal Vein Embolization Only before Major Hepatectomy for Patients with Hepatocellular Carcinoma [Elektronische Daten] [Hyunkyung Yoo, Jin Kim, Gi-Young Ko, Kyoung Kim, Dong Gwon, Sung-Gyu Lee, Shin Hwang] Purpose: To evaluate the safety and efficacy of sequential transcatheter arterial chemoembolization (TACE) and portal vein embolization (PVE) prior to surgery in hepatocellular carcinoma (HCC) patients and to compare the clinical outcome of the combined procedure with that of a matched group of patients undergoing PVE alone. Patients and Methods: From 1997 to 2008, 135 patients with HCC underwent sequential TACE and PVE (n=71) or PVE alone (n=64) before right hepatectomy. PVE was performed mean 1.2months after TACE. In both groups, computed tomography (CT) and liver volumetry were performed before and 2weeks after PVE to assess degree of left lobe hypertrophy. Results: Baseline patient and tumor characteristics were similar in the two groups. After PVE, the chronological changes of liver enzymes were similar in the two groups. The mean increase in percentage future liver remnant (FLR) volume was higher in the TACE+PVE group (7.3%) than in the PVE-only group (5.8%) (P=0.035). After surgery, incidence of hepatic failure was higher in the PVE-only group (12%) than in the TACE+PVE (4%) group (P=0.185). Overall (P=0.028) and recurrence-free (P=0.001) survival rates were significantly higher in the TACE+PVE group than in the PVE-only group. Conclusion: Sequential TACE and PVE before surgery is a safe and effective method to increase the rate of hypertrophy of the FLR and leads to longer overall and recurrence-free survival in patients with HCC. Society of Surgical Oncology, 2010 Yoo Hyunkyung Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Kim Jin Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Ko Gi-Young Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Kim Kyoung Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Gwon Dong Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Lee Sung-Gyu Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Hwang Shin Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1251-1257 1068-9265 18:5<1251 2011 18 10434 https://doi.org/10.1245/s10434-010-1423-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1423-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoo Hyunkyung Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jin Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Ko Gi-Young Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyoung Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Gwon Dong Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Sung-Gyu Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Hwang Shin Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1251-1257 1068-9265 18:5<1251 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer