caa a22 4500 445336927 CHVBK 20180317142759.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1472-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1472-7 Efficacy of Para-Aortic Lymphadenectomy in Early-Stage Endometrioid Uterine Corpus Cancer [Elektronische Daten] [Seo-Yun Tong, Jong-Min Lee, Jae-Kwan Lee, Jae Kim, Chi-Heum Cho, Seok-Mo Kim, Sang-Yoon Park, Chan-Yong Park, Ki-Tae Kim] Purpose: The objective of this study was to assess whether para-aortic lymphadenectomy has therapeutic efficacy for patients with early-stage endometrioid uterine cancer who underwent systematic pelvic lymphadenectomy. Methods: The authors retrospectively reviewed the medical records and pathological findings of 547 patients with histologically proven FIGO stage I-II endometrioid uterine cancer, based on comprehensive surgical staging, including pelvic with or without para-aortic lymphadenectomy. Results: Among 547 patients, 330 patients had systematic pelvic lymphadenectomy only, and 217 had systematic pelvic with para-aortic lymphadenectomy. There were no significant differences in histopathological factors in the high-risk group, even though deep myometrial invasion (p=0.02) and lymphvascular space invasion (p=0.01) were more common in patients who underwent systematic pelvic with para-aortic lymphadenectomy in all study populations. Within a median follow-up of 31 (range, 5-120) months, there was no significant difference in overall survival between the pelvic lymphadenectomy only and pelvic with para-aortic lymphadenectomy groups in all populations (p=0.77), even in high-risk patients (p=0.82). Upon multivariate analysis, patients with lymphvascular space invasion had significantly worse overall survival (odds ratio (OR)=7.38; 95% confidence interval (CI)=1.86-29.23; p=0.004). Conclusions: Although a prospective, randomized study needs to be performed for confirmation, our data suggest that the therapeutic benefit of para-aortic lymphadenectomy is uncertain in stage I and II endometrioid uterine corpus cancer, even in patients at high-risk for recurrence. Society of Surgical Oncology, 2010 Tong Seo-Yun Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, Korea aut Lee Jong-Min Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, Korea aut Lee Jae-Kwan Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea aut Kim Jae Department of Obstetrics and Gynecology & Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea aut Cho Chi-Heum Department of Obstetrics and Gynecology, Dongsan Medical Center, Keimyung University, Daegu, Korea aut Kim Seok-Mo Department of Obstetrics and Gynecology, Chonnam National University, Gwangju, Korea aut Park Sang-Yoon Center for Uterine Cancer, National Cancer Center, Goyang, Korea aut Park Chan-Yong Department of Obstetrics and Gynecology, Gachon University Gil Hospital, Incheon, Korea aut Kim Ki-Tae Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, Busan, Korea aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1425-1430 1068-9265 18:5<1425 2011 18 10434 https://doi.org/10.1245/s10434-010-1472-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1472-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tong Seo-Yun Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jong-Min Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jae-Kwan Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jae Department of Obstetrics and Gynecology & Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Chi-Heum Department of Obstetrics and Gynecology, Dongsan Medical Center, Keimyung University, Daegu, Korea aut NATIONALLICENCE 700 1- Kim Seok-Mo Department of Obstetrics and Gynecology, Chonnam National University, Gwangju, Korea aut NATIONALLICENCE 700 1- Park Sang-Yoon Center for Uterine Cancer, National Cancer Center, Goyang, Korea aut NATIONALLICENCE 700 1- Park Chan-Yong Department of Obstetrics and Gynecology, Gachon University Gil Hospital, Incheon, Korea aut NATIONALLICENCE 700 1- Kim Ki-Tae Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, Busan, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1425-1430 1068-9265 18:5<1425 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer