caa a22 4500 445336943 CHVBK 20180317142759.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1489-y doi (NATIONALLICENCE)springer-10.1245/s10434-010-1489-y Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma [Elektronische Daten] [Mu-Kuan Chen, Chih-Ming Chen, Ming-Che Lee, Li-Sheng Chen, Hui-Chuan Chen] Background: We evaluated the heterogeneity of primary tumor volume (PTV) within tumors of the same pT4a-staged tongue carcinoma and to elucidate the effects of PTV on treatment outcomes in patients with pT4a-staged tongue carcinoma. Methods: Fifty-eight patients with newly diagnosed pT4a-staged tongue carcinoma who received surgery were enrolled onto this study. Magnetic resonance imaging-derived PTV was measured by the summation-of-area technique. Results: The mean PTV was 24.55ml, with a range of 5.32 to 119.64ml. The receiver operating characteristic curve was applied, and the optimal cutoff volume was 23ml. Large PTV was associated with a significantly poor disease-specific survival (P=0.010) by the log rank test. The Cox regression model also revealed that large PTV (P=0.026) and positive lymphatic node metastasis (P=0.004) were statistically significant in the prognosis of T4a-staged tongue carcinoma. Conclusions: A substantial variation of PTV was present within the same pT4a-staged tongue carcinoma, and PTV represented an important prognostic factor. In the light of these findings, we suggest that taking the PTV into account in pT4a-staged tongue carcinoma would better refine the newest revised T classification, and the treatment strategies may be different. The Author(s), 2010 Chen Mu-Kuan Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan aut Chen Chih-Ming Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan aut Lee Ming-Che Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan aut Chen Li-Sheng Laboratory of Biostatistics, Changhua Christian Hospital, Changhua, Taiwan aut Chen Hui-Chuan Providence University, Taichung, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1447-1452 1068-9265 18:5<1447 2011 18 10434 https://doi.org/10.1245/s10434-010-1489-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1489-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Mu-Kuan Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan aut NATIONALLICENCE 700 1- Chen Chih-Ming Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan aut NATIONALLICENCE 700 1- Lee Ming-Che Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan aut NATIONALLICENCE 700 1- Chen Li-Sheng Laboratory of Biostatistics, Changhua Christian Hospital, Changhua, Taiwan aut NATIONALLICENCE 700 1- Chen Hui-Chuan Providence University, Taichung, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1447-1452 1068-9265 18:5<1447 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer