caa a22 4500 445336951 CHVBK 20180317142759.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1431-3 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1431-3 Metallothionein-1 Genotypes in the Risk of Oral Squamous Cell Carcinoma [Elektronische Daten] [A. Zavras, A. Yoon, M. Chen, C. Lin, S. Yang] Background: We conducted an independent analysis of metallothionein 1 (MT-1) rs8052394, rs11076161, rs8052334, rs964372, rs7191779, and rs708274 in 587 individuals who were either healthy controls or subjects with oral squamous cell carcinoma (OSCC). Methods: All participants provided a nucleic acid sample (blood) as well as epidemiologic information on covariates or "risk factors” for OSCC, including tobacco, alcohol, and areca quid use. The genotyping result was used in a logistic regression model that examined main effects as well as statistical interactions while controlling for confounders. Results: MT-1 is involved in regulation of zinc and copper homeostasis. It also is a potent antioxidant and its polymorphisms correlate with the risk for OSCC. Rs11076161 A, rs964372 C, and rs7191779 C alleles were protective against OSCC (adjusted OR=0.53, 0.49, 0.36, respectively; p<0.05), whereas rs8052394 A alleles were associated with increased risk. Areca quid chewing and tobacco use were strong risk factors for developing the disease and were associated with 20- and 8-fold increases in adjusted risk (p<0.05), respectively. Conclusions: Controlling for the effects of age, gender, areca quid, tobacco, and alcohol use, individuals with inherited the MT-1 rs11076161 AA, rs964372 CC, and rs7191779 GC genotypes may experience significant protection against OSCC, whereas individuals carrying the MT-1 rs8052394 A allele seem exposed to higher risk. Society of Surgical Oncology, 2010 Zavras A. Faculty of Dentistry, College of Dental Medicine, Columbia University, New York, NY, USA aut Yoon A. Faculty of Dentistry, College of Dental Medicine, Columbia University, New York, NY, USA aut Chen M. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC aut Lin C. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan aut Yang S. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1478-1483 1068-9265 18:5<1478 2011 18 10434 https://doi.org/10.1245/s10434-010-1431-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1431-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zavras A. Faculty of Dentistry, College of Dental Medicine, Columbia University, New York, NY, USA aut NATIONALLICENCE 700 1- Yoon A. Faculty of Dentistry, College of Dental Medicine, Columbia University, New York, NY, USA aut NATIONALLICENCE 700 1- Chen M. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC aut NATIONALLICENCE 700 1- Lin C. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan aut NATIONALLICENCE 700 1- Yang S. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1478-1483 1068-9265 18:5<1478 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer