caa a22 4500 44533701X CHVBK 20180317142759.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1245/s10434-010-1407-3 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1407-3 Different Distribution of Breast Cancer Subtypes in Breast Ductal Carcinoma in situ (DCIS), DCIS with Microinvasion, and DCIS with Invasion Component [Elektronische Daten] [Ke-Da Yu, La-Mu Wu, Guang-Yu Liu, Jiong Wu, Gen-Hong Di, Zhen-Zhou Shen, Zhi-Ming Shao] Background: Breast ductal carcinoma in situ with microinvasion (DCIS-Mi) is considered to be the interim stage in the progression from DCIS to invasive breast cancer (IDC). Cases that exceed DCIS-Mi but still do not fulfill the diagnostic criteria of IDC often are observed. We define those cases as DCIS with invasion component (DCIS-I), and attempt to study the differences of clinicopathological features and immunohistochemical-based subtypes among DCIS, DCIS-Mi, and DCIS-I. Methods: In this retrospective study, 550 consecutive DCIS patients were recruited, 271 (49.3%) cases were diagnosed as pure-DCIS, 67 as DCIS-Mi, and 212 as DCIS-I. They were categorized into four groups: luminal-A (ER+ and/or PR+, HER2−), luminal-B (ER+ and/or PR+, HER2+), ERBB2+ (ER−, PR−, HER2+), and basal-like (ER−, PR−, HER2−). Results: DCIS-Mi and DCIS-I patients tended to have larger tumors with highly graded nuclear (P=0.011 for size; P<0.0001 for nuclear grade). The proportion of luminal-like tumors decreased, whereas ERBB2+ and basal-like tumors increased in DCIS-I/DCIS-Mi compared with pure-DCIS (P=0.039). Although the HER2-positive tumors displayed a stable proportion among DCIS subgroups, the essences of them were varying. In pure-DCIS, luminal-B was the major subtype of HER2-positive tumors (luminal-B vs. ERBB2+, 19% vs. 14.6%), whereas in DCIS-I, the proportion of luminal-B decreased vastly (luminal-B vs. ERBB2+, 12.8% vs. 23.5%). DCIS-I had a worse relapse-free survival outcome compared with pure-DCIS. Conclusions: Different distribution of subtypes and distinctive characteristics among DCIS, DCIS-Mi, and DCIS-I indicate that they are distinct entities. Further studies with larger sample size are needed to replicate our observations. Society of Surgical Oncology, 2010 Yu Ke-Da Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut Wu La-Mu Department of Surgery, Hami Diqu Hospital, Hami, Xinjiang, People's Republic of China aut Liu Guang-Yu Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut Wu Jiong Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut Di Gen-Hong Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut Shen Zhen-Zhou Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut Shao Zhi-Ming Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1342-1348 1068-9265 18:5<1342 2011 18 10434 https://doi.org/10.1245/s10434-010-1407-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1407-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Ke-Da Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Wu La-Mu Department of Surgery, Hami Diqu Hospital, Hami, Xinjiang, People's Republic of China aut NATIONALLICENCE 700 1- Liu Guang-Yu Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Wu Jiong Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Di Gen-Hong Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Shen Zhen-Zhou Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Shao Zhi-Ming Department of Breast Surgery, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/5(2011-05-01), 1342-1348 1068-9265 18:5<1342 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer