caa a22 4500 445337354 CHVBK 20180317142800.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-009-0704-1 doi (NATIONALLICENCE)springer-10.1245/s10434-009-0704-1 Axillary Recurrence Rate Following Negative Sentinel Node Biopsy for Invasive Breast Cancer: Long-Term Follow-Up [Elektronische Daten] [John Kiluk, Quan Ly, Tammi Meade, Daniel Ramos, Douglas Reintgen, Sophie Dessureault, Michelle Davis, Corinne Shamehdi, Charles Cox] Objective: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) as the definitive nodal staging procedure for breast cancer. SLN biopsy has been proven to cause less morbidity and be more cost effective than complete ALND. Short-term follow-up has shown that lymphatic mapping and SLN have a low false-negative rate, but there is limited data demonstrating long-term outcomes within a large consecutive series of patients. Methods: Retrospective review of a prospective database of breast cancer patients at our institution was performed. The initial mapping of 1,530 patients with invasive breast cancer who demonstrated a negative sentinel node biopsy and no axillary dissection between January 1995 and June 2003 were collated and reviewed to achieve a long-term follow-up. These 1,530 patients were reviewed for follow-up time, local recurrences, distant metastases, and survival. Results: 1,530 consecutively mapped invasive breast cancer patients had a negative SLN biopsy and no ALND. The mean invasive tumor size was 1.40cm. Of 1,530 patients, 73% (1,121) underwent lumpectomy and 27% (409) underwent mastectomy. Mean follow-up was 4.92years (range 0-12.0years). There have been 4 (0.26%) patients presenting with local axillary recurrences, 54 (3.53%) patients presenting with local recurrences in the ipsilateral breast/chest wall, and 24 (1.57%) presenting with distant metastases. Conclusion: These data confirm that SLN biopsy is an effective and safe alternative to ALND for detection of nodal metastases in patients with invasive breast cancer and should be used as the standard tool for nodal staging. Society of Surgical Oncology, 2009 Kiluk John H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Ly Quan University of Nebraska Medical Center, Omaha, NE, USA aut Meade Tammi H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Ramos Daniel H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Reintgen Douglas Lakeland Regional Cancer Center, Lakeland, FL, USA aut Dessureault Sophie H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Davis Michelle H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Shamehdi Corinne H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Cox Charles H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut Annals of Surgical Oncology Springer-Verlag 18(2011-12-01), 339-342 1068-9265 18<339 2011 18 10434 https://doi.org/10.1245/s10434-009-0704-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-009-0704-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kiluk John H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 700 1- Ly Quan University of Nebraska Medical Center, Omaha, NE, USA aut NATIONALLICENCE 700 1- Meade Tammi H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 700 1- Ramos Daniel H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 700 1- Reintgen Douglas Lakeland Regional Cancer Center, Lakeland, FL, USA aut NATIONALLICENCE 700 1- Dessureault Sophie H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 700 1- Davis Michelle H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 700 1- Shamehdi Corinne H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 700 1- Cox Charles H. Lee Moffitt Cancer Center and Research Institute (MCC), Tampa, FL, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18(2011-12-01), 339-342 1068-9265 18<339 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer