caa a22 4500 445338032 CHVBK 20180317142802.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1294-7 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1294-7 Feasibility of Preservation of the Submandibular Gland During Neck Dissection in Patients With Early-Stage Oral Cancer [Elektronische Daten] [Tseng-Cheng Chen, Pei-Jen Lou, Jenq-Yuh Ko, Tsung-Lin Yang, Wu-Chia Lo, Ya-Ling Hu, Cheng-Ping Wang] Background: The impact of submandibular gland (SMG) preservation during neck dissection on the survival of patients with early-stage oral squamous-cell carcinoma (OSCC) remains undocumented. Methods: The medical records of all patients with early-stage OSCC (stage I and II) who underwent wide excision of the primary tumor and simultaneous neck dissection between 1999 and 2006 at our facility were retrospectively reviewed. Results: We analyzed 408 patients, including 33 patients with and 375 patients without SMG preservation. The 5-year disease-free and overall survival rates were 78.8% and 90.9% for the patients with SMG preservation and 75.4% and 90.4% for the patients without SMG preservation, and these differences were not statistically significant (P=0.79, P=0.99, respectively). Similar survival rates between patients with and without SMG preservation were observed in those with oral tongue squamous-cell carcinoma (SCC) and with buccal SCC. Patients with T2 OSCC with SMG preservation had significantly lower 5-year disease-free survival rate than those without SMG preservation (P=0.02), but overall survival rates were similar between these two groups. Conclusions: Preservation of the SMG during neck dissection may be oncologically safe in patients with T1 OSCC, but the feasibility of SMG preservation seems less clear for T2 OSCC. Society of Surgical Oncology, 2010 Chen Tseng-Cheng Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut Lou Pei-Jen Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut Ko Jenq-Yuh Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut Yang Tsung-Lin Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut Lo Wu-Chia Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan aut Hu Ya-Ling Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut Wang Cheng-Ping Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 497-504 1068-9265 18:2<497 2011 18 10434 https://doi.org/10.1245/s10434-010-1294-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1294-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Tseng-Cheng Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lou Pei-Jen Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Ko Jenq-Yuh Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Yang Tsung-Lin Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lo Wu-Chia Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Hu Ya-Ling Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wang Cheng-Ping Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 497-504 1068-9265 18:2<497 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer