caa a22 4500 445338059 CHVBK 20180317142802.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1275-x doi (NATIONALLICENCE)springer-10.1245/s10434-010-1275-x Sentinel Node Biopsy in Squamous-Cell Carcinoma of the Anal Canal [Elektronische Daten] [Paola De Nardi, Michele Carvello, Carla Canevari, Paolo Passoni, Carlo Staudacher] Background: Radiochemotherapy is the standard treatment for patients with carcinoma of the anal canal. Therefore, a surgical specimen is not usually obtained. Inguinal lymph node metastases cannot be accurately predicted by either clinical examination or imaging techniques. In this study, we applied the sentinel node technique in patients with anal canal squamous-cell carcinoma to determine whether this provided more reliable staging of tumors. Methods: From May 2007 to May 2009, we enrolled 11 patients (7 women) with a mean age 65 (range 39-80) years with squamous-cell carcinoma of the anal canal and clinically and radiologically negative groin lymph nodes. The patients were staged with endorectal ultrasound, computed tomographic scan, magnetic resonance imaging of the pelvis, and positron emission tomography. There were two T1, four T2, and five T3 tumors (International Union Against Cancer classification). Lymphoscintigraphy with peritumoral 99mTc colloid injection was performed 16 to 18h before surgery. During the surgery, patent blue dye was injected peritumorally, and the sentinel inguinal node was identified by a handheld gamma probe and dye visualization. Results: The sentinel lymph node was detected in all 11 patients by scintigraphy; in 9 cases, the lymph node was in the inguinal region. All of these patients underwent radioguided node biopsy, and a total of 12 lymph nodes were removed. The average diameter of the resected nodes was 8 (range 4-20) mm. No serious complications occurred. In three patients, metastases were identified in the lymph node. Conclusions: Sentinel node biopsy is a more accurate method than clinical or radiological techniques to stage the disease of patients with anal carcinoma. Society of Surgical Oncology, 2010 De Nardi Paola Department of Surgery, Scientific Institute San Raffaele Hospital, Milan, Italy aut Carvello Michele Department of Surgery, Scientific Institute San Raffaele Hospital, Milan, Italy aut Canevari Carla Department of Nuclear Medicine, Scientific Institute San Raffaele Hospital, Milan, Italy aut Passoni Paolo Department of Radiotherapy, Scientific Institute San Raffaele Hospital, Milan, Italy aut Staudacher Carlo Department of Surgery, Scientific Institute San Raffaele Hospital, Milan, Italy aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 365-370 1068-9265 18:2<365 2011 18 10434 https://doi.org/10.1245/s10434-010-1275-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1275-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Nardi Paola Department of Surgery, Scientific Institute San Raffaele Hospital, Milan, Italy aut NATIONALLICENCE 700 1- Carvello Michele Department of Surgery, Scientific Institute San Raffaele Hospital, Milan, Italy aut NATIONALLICENCE 700 1- Canevari Carla Department of Nuclear Medicine, Scientific Institute San Raffaele Hospital, Milan, Italy aut NATIONALLICENCE 700 1- Passoni Paolo Department of Radiotherapy, Scientific Institute San Raffaele Hospital, Milan, Italy aut NATIONALLICENCE 700 1- Staudacher Carlo Department of Surgery, Scientific Institute San Raffaele Hospital, Milan, Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 365-370 1068-9265 18:2<365 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer