caa a22 4500 445338067 CHVBK 20180317142802.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1244-4 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1244-4 Impact of Circumferential Resection Margin Distance on Locoregional Recurrence and Survival after Chemoradiotherapy in Esophageal Squamous Cell Carcinoma [Elektronische Daten] [Yin-Kai Chao, Chi-Ju Yeh, Hsien-Kun Chang, Chen-Kan Tseng, Yin-Yi Chu, Ming-Ju Hsieh, Yi-Cheng Wu, Hui-Ping Liu] Background: Close circumferential resection margin (CRM) is an established predictor for locoregional recurrence (LR) in rectal cancer but remains controversial in esophageal malignancy. As yet, little is known about the significance of CRM after chemoradiotherapy (CRT), especially in squamous cell carcinoma (SCC). This study investigated the relationship between CRM distance and recurrence after neoadjuvant CRT in esophageal SCC patients. Methods: Between 1997 and 2005, esophageal SCC patients who underwent surgery after neoadjuvant CRT and with pathology stage T3N0M0 and T3N1M0 (metastatic lymph nodes <2) were selected. CRM distance was reassessed and divided into three groups (group 1: CRM >1mm, group 2: uninvolved CRM but <1mm, group 3: CRM involved). Results: The cohort comprised 145 male and 6 female patients with mean age of 57years. There were 74, 51, and 26 patients in group 1, 2, and 3, respectively. With median follow-up period of 50months, LR developed in 30.5% of patients. Both group 2 and group 3 had significantly higher LR than group 1 (37 and 42% vs. 21%, P<0.05). Meanwhile, mean time from operation to recurrence was also significantly shorter in group 2 and group 3 than in group 1 (267 and 269days versus 402days, P<0.05). Five-year disease-specific survival (DSS) was highest in group 1 (40%). Despite the similarity in LR, 5-year DSS significantly differed between group 2 and group 3 (22 vs. 7%, P<0.05). The higher rate of distant recurrence (DR) and concomitant LR+DR in group 3 accounted for the survival difference. Conclusion: In ypT3 esophageal SCC patients, CRM distance provides useful information for risk stratification in cancer recurrence and survival. Society of Surgical Oncology, 2010 Chao Yin-Kai Graduate Institute of Clinical Medical Sciences, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Yeh Chi-Ju Department of Pathology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Chang Hsien-Kun Division of Haematology/Oncology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Tseng Chen-Kan Department of Radiation Oncology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Chu Yin-Yi Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Hsieh Ming-Ju Division of Thoracic Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Wu Yi-Cheng Division of Thoracic Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut Liu Hui-Ping Division of Thoracic Surgery, BENQ Medical Center, Jianye District, Nanjing, China aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 529-534 1068-9265 18:2<529 2011 18 10434 https://doi.org/10.1245/s10434-010-1244-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1244-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chao Yin-Kai Graduate Institute of Clinical Medical Sciences, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Yeh Chi-Ju Department of Pathology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Chang Hsien-Kun Division of Haematology/Oncology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Tseng Chen-Kan Department of Radiation Oncology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Chu Yin-Yi Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Hsieh Ming-Ju Division of Thoracic Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Wu Yi-Cheng Division of Thoracic Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Liu Hui-Ping Division of Thoracic Surgery, BENQ Medical Center, Jianye District, Nanjing, China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 529-534 1068-9265 18:2<529 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer