caa a22 4500 445338113 CHVBK 20180317142802.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1318-3 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1318-3 Sentinel Node Dissection Delays Recurrence and Prolongs Melanoma-Related Survival: An Analysis of 673 Patients from a Single Center with Long-Term Follow-Up [Elektronische Daten] [I. Satzger, A. Meier, L. Hoy, B. Völker, A. Kapp, A. Hauschild, R. Gutzmer] Background: The status of the sentinel lymph node is an important predictor for survival in melanoma patients, but it is still unclear if early removal of micrometastases by sentinel lymph node dissection (SLND) alters survival. A large series of melanoma patients from a single center with long-term follow-up was analyzed with regard to a possible effect of SLND on the prognosis. Materials and Methods: A total of 673 consecutive melanoma patients were assessed treated in our center either without SLND (377 patients, pre-SLN group, between January 1995 and March 2000) or with SLND (296 patients, SLN group, between April 2000 and March 2003). The median follow-up was 64.0months in the pre-SLN and 72.5months in the SLN group. Results: The pre-SLN group and SLN group did not differ significantly with regard to characteristics of the primary melanoma thickness and ulceration, sex, and age. Kaplan-Meier analyses showed a significantly better recurrence-free survival (P<.001), distant metastases free survival (P=.006), and overall survival (P=.049) for patients of the SLN group; the 5-year melanoma-specific survival rates were 80.3% in pre-SLN patients and 84.8% in SLN patients. Initial metastases in the in-transit region and distant locations were of similar frequency in the pre-SLN and SLN groups (P=.191 and P=.959, respectively), but initial regional lymph node metastases were significantly more frequent in the pre-SLN group (P<.001). Conclusions: Our data point toward a subgroup of melanoma patients who might have a prognostic benefit from SLN. Society of Surgical Oncology, 2010 Satzger I. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut Meier A. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut Hoy L. Institut of Biometrics, Hannover Medical School, Hannover, Germany aut Völker B. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut Kapp A. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut Hauschild A. Department of Dermatology, University of Kiel, Kiel, Germany aut Gutzmer R. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 514-520 1068-9265 18:2<514 2011 18 10434 https://doi.org/10.1245/s10434-010-1318-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1318-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Satzger I. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Meier A. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Hoy L. Institut of Biometrics, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Völker B. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Kapp A. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Hauschild A. Department of Dermatology, University of Kiel, Kiel, Germany aut NATIONALLICENCE 700 1- Gutzmer R. Skin Cancer Centre Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 514-520 1068-9265 18:2<514 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer