caa a22 4500 445338164 CHVBK 20180317142802.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1309-4 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1309-4 Invasive IPMN and MCN: Same Organ, Sifferent Outcomes? [Elektronische Daten] [Hamed Kargozaran, Vu Vu, Partha Ray, Sanjay Bagaria, Shawn Steen, Xing Ye, Singh Gagandeep] Background: The efficacy of surgery for invasive mucinous neoplasms is unclear. We examined the natural history of invasive mucinous cystic neoplasms (MCN) and invasive intraductal papillary mucinous neoplasms (IPMN) in patients who underwent pancreatic resection. Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1996-2006) was queried for cases of resected invasive MCN and IPMN. Demographics, tumor characteristics, and overall survival were examined using log-rank analysis and multivariate Cox regression model. Results: Of 185 MCN cases and 641 IPMN cases, 73% and 48%, respectively, were women (P<0.0001). Most (73%) IPMN were in the head of the pancreas; most (64%) MCN were in the tail/body (P<0.0001). Lymph node metastasis was more common for IPMN than MCN (46% vs. 24%, P<0.0001). Overall survival after resection was better for patients with stage I MCN vs. stage I IPMN (P=0.0005), and it was better for patients with node-negative MCN vs. node-negative IPMN (P=0.0061). There was no significant difference in survival of patients with stage IIA MCN vs. stage IIA IPMN (P=0.5964), stage IIB MCN vs. stage IIB IPMN (P=0.2262), or node-positive MCN vs. node-positive IPMN (P=0.2263). Age older than 65years (hazards ratio (HR) 1.71, P=0.0046), high tumor grade (HR 2.68, P<0.0001), higher T stage (HR 2.11, P<0.0001), and IPMN histology (HR 1.90, P=0.0040) predicted worse outcome in node-negative patients. Conclusions: Our findings suggest that survival is better after resection of invasive MCN versus invasive IPMN when disease is localized within the pancreas, but this difference disappears in the presence of nodal metastasis or extrapancreatic extension. Society of Surgical Oncology, 2010 Kargozaran Hamed Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Vu Vu Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Ray Partha Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Bagaria Sanjay Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Steen Shawn Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Ye Xing Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Gagandeep Singh Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 345-351 1068-9265 18:2<345 2011 18 10434 https://doi.org/10.1245/s10434-010-1309-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1309-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kargozaran Hamed Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Vu Vu Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Ray Partha Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Bagaria Sanjay Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Steen Shawn Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Ye Xing Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Gagandeep Singh Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 345-351 1068-9265 18:2<345 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer