caa a22 4500 445338369 CHVBK 20180317142803.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1219-5 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1219-5 Tumor Depth as a Predictor of Lymph Node Metastasis of Supraglottic and Hypopharyngeal Cancers [Elektronische Daten] [Masayuki Tomifuji, Yorihisa Imanishi, Koji Araki, Taku Yamashita, Sohei Yamamoto, Kaori Kameyama, Akihiro Shiotani] Background: The relationship between the histological parameters of primary lesions and lymph node metastasis in supraglottic and hypopharyngeal cancers has not been elucidated. This analysis is important to evaluate the requirement for additional elective neck dissection when clinically node-negative cancers are treated by transoral surgery. Methods: This study included 40 previously untreated patients with supraglottic and hypopharyngeal cancers who underwent transoral en bloc tumor resection in two academic tertiary referral centers. Nodal status was confirmed by neck dissection for cases with findings or suspicion of lymph node metastases or by observation of clinically node-negative cases for more than 1year. Patients' medical records and pathological features were analyzed retrospectively. The correlation of histological parameters with lymph node metastases, including occult metastases, was evaluated by univariate and multiple logistic regression analyses. Results: Univariate analysis showed that lymph node metastasis was correlated with tumor depth (P=0.00087) and venous invasion (P=0.027). Multiple logistic regression analysis showed that it was significantly correlated only with tumor depth (P=0.007). Conclusions: Tumor depth is the most useful parameter for predicting lymph node metastases. In clinically node-negative cases, when tumor depth exceeds 1mm, elective neck dissection must be considered and, when it is less than 0.5mm, regular clinical follow-up is recommended. Patients with tumor depth between 0.5 and 1mm should be carefully observed, since they also have a chance of developing nodal metastasis. Venous invasion also indicates high rates of nodal metastasis, therefore elective neck dissection must be considered for these cases. Society of Surgical Oncology, 2010 Tomifuji Masayuki Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut Imanishi Yorihisa Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan aut Araki Koji Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut Yamashita Taku Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut Yamamoto Sohei Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan aut Kameyama Kaori Department of Pathology, Keio University School of Medicine, Tokyo, Japan aut Shiotani Akihiro Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 490-496 1068-9265 18:2<490 2011 18 10434 https://doi.org/10.1245/s10434-010-1219-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1219-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomifuji Masayuki Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Imanishi Yorihisa Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Araki Koji Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Yamashita Taku Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Yamamoto Sohei Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Kameyama Kaori Department of Pathology, Keio University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Shiotani Akihiro Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 490-496 1068-9265 18:2<490 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer