caa a22 4500 44533844X CHVBK 20180317142803.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1329-0 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1329-0 Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer [Elektronische Daten] [Nam Nguyen, Misty Ceizyk, Fabio Almeida, Alexander Chi, Michael Betz, Homayoun Modarresifar, Thomas Sroka, Deirdre Cohen, Siyoung Jang, Dave Abraham, Michelle Stevie, Lexie Smith-Raymond, Shane Krafft, Vincent Vinh-Hung] Background: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. Methods: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. Results: Nineteen patients (median age, 69years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group—patients who had pCR and those who did not have pCR—was 14, 17, and 15months, respectively. Conclusions: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials. Society of Surgical Oncology, 2010 Nguyen Nam Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Ceizyk Misty Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Almeida Fabio Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Chi Alexander Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Betz Michael Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland aut Modarresifar Homayoun Department of Nuclear Medicine, University of Arizona, Tucson, AZ, USA aut Sroka Thomas Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Cohen Deirdre Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Jang Siyoung Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Abraham Dave Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Stevie Michelle Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Smith-Raymond Lexie Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Krafft Shane Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut Vinh-Hung Vincent Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 380-385 1068-9265 18:2<380 2011 18 10434 https://doi.org/10.1245/s10434-010-1329-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1329-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nguyen Nam Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Ceizyk Misty Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Almeida Fabio Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Chi Alexander Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Betz Michael Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland aut NATIONALLICENCE 700 1- Modarresifar Homayoun Department of Nuclear Medicine, University of Arizona, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Sroka Thomas Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Cohen Deirdre Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Jang Siyoung Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Abraham Dave Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Stevie Michelle Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Smith-Raymond Lexie Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Krafft Shane Department of Radiation Oncology, University of Arizona, 1501N. Campbell Ave, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Vinh-Hung Vincent Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 380-385 1068-9265 18:2<380 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer