caa a22 4500 445338482 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1340-5 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1340-5 Predictors of Breast Cancer Development in Women with Atypical Ductal Hyperplasia and Atypical Lobular Hyperplasia [Elektronische Daten] [Amy Whiffen, Mahmoud El-Tamer, Brett Taback, Sheldon Feldman, Kathie-Ann Joseph] Background: Atypical ductal hyperplasia and atypical lobular neoplasia are common benign breast diseases that increase breast cancer risk. We performed a cohort analysis that compared atypia patients for additional risk factors to asses the effect on breast cancer risk by atypia status. Methods: This longitudinal cohort study used data from the Women At Risk High-Risk Registry at Columbia University Medical Center, New York. Women with atypia were compared to women without atypia across known risk factors to determine the combined effect on breast cancer development. Odds ratios (ORs) stratified by atypia status were calculated for each risk factor of interest with 95% confidence intervals (95% CIs). P values were calculated to determine statistical significance. Results: The study population included 1598 high-risk women, 921 (57.6%) of whom had a history of biopsy-proven atypia. The remaining 677 high-risk women (42.4%) did not have atypia. Fifty women (3.1%) developed breast cancer. Alcohol was significantly associated with the development of breast cancer (P=0.02) and increased breast cancer risk among women with atypia (OR, 2.13; 95% CI, 0.95-4.81) compared to women without atypia (OR, 1.71). The odds of breast cancer were higher for atypia patients with first-degree relatives (OR, 1.48; 95% CI, 0.64-3.35) compared to women with a relative and no atypia diagnosis (OR, 0.98; 95% CI, 0.41-2.63). The other risk factors of interest did not differ significantly by atypia status. Conclusions: Atypia patients who drank alcohol and had a first-degree relative with breast cancer have an increased risk of breast cancer compared to those without atypia. Continued understanding of the high-risk population will lead to more individualized protocols for risk reduction and prevention. Society of Surgical Oncology, 2010 Whiffen Amy Women At Risk, NewYork Presbyterian Hospital, New York, NY, USA aut El-Tamer Mahmoud Breast Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA aut Taback Brett Comprehensive Breast Center, Columbia University Medical Center, New York, NY, USA aut Feldman Sheldon Comprehensive Breast Center, Columbia University Medical Center, New York, NY, USA aut Joseph Kathie-Ann Women At Risk, NewYork Presbyterian Hospital, New York, NY, USA aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 463-467 1068-9265 18:2<463 2011 18 10434 https://doi.org/10.1245/s10434-010-1340-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1340-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Whiffen Amy Women At Risk, NewYork Presbyterian Hospital, New York, NY, USA aut NATIONALLICENCE 700 1- El-Tamer Mahmoud Breast Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Taback Brett Comprehensive Breast Center, Columbia University Medical Center, New York, NY, USA aut NATIONALLICENCE 700 1- Feldman Sheldon Comprehensive Breast Center, Columbia University Medical Center, New York, NY, USA aut NATIONALLICENCE 700 1- Joseph Kathie-Ann Women At Risk, NewYork Presbyterian Hospital, New York, NY, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 463-467 1068-9265 18:2<463 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer