caa a22 4500 445338512 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1245/s10434-010-1287-6 doi (NATIONALLICENCE)springer-10.1245/s10434-010-1287-6 Incidental Thyroid Carcinoma by FDG-PET/CT: A Study of Clinicopathological Characteristics [Elektronische Daten] [T. Law, Brian Lang] Background: The rising incidence of incidental thyroid carcinoma (ITC) detected during fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning poses a challenge to clinicians. The present study aims to critically evaluate the clinicopathological characteristics of ITC detected by FDG-PET/CT. Methods: Among the 557 patients managed at our institution, 40 (7.2%) patients were identified as having ITC. Of these, 22 patients had their tumor detected by FDG-PET/CT (PET group) and 11 by ultrasonography (USG group). Additional bedside ultrasonography±fine-needle aspiration (FNA) was done in all patients at their clinic visit. The clinicopathological characteristics were compared between the PET and USG groups. Results: The PET group had significantly more patients with history of nonthyroidal malignancy (P<0.001). Papillary carcinoma was the most common histological type in both groups. Despite having similar histological and prognostic features including tumor size, tumor multifocality, capsular invasion, extrathyroidal extension, and lymph node metastases, tumor bilaterality (or presence of contralateral tumor focus) was significantly more frequent in the PET than the USG group (P=0.04). The tumors were also more advanced by the tumor-node-metastasis (TNM) staging system in the PET group (P=0.021). None of the contralateral tumor foci were evident preoperatively. One patient in the USG group developed metastatic thyroid carcinoma in neck lymph nodes 28months after thyroid resection. Conclusion: ITC by FDG-PET/CT had higher incidence of tumor bilaterality than those detected by ultrasonography. Total thyroidectomy should be considered for ITC detected by FDG-PET/CT even for tumor size <10mm. The Author(s), 2010 Law T. Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Hong Kong SAR, China aut Lang Brian Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Hong Kong SAR, China aut Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 472-478 1068-9265 18:2<472 2011 18 10434 https://doi.org/10.1245/s10434-010-1287-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-010-1287-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Law T. Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Lang Brian Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/2(2011-02-01), 472-478 1068-9265 18:2<472 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer