caa a22 4500 445338520 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1826-9 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1826-9 Factors Predictive of the Status of Sentinel Lymph Nodes in Melanoma Patients from a Large Multicenter Database [Elektronische Daten] [Richard White Jr., Gregory Ayers, Virginia Stell, Shouluan Ding, Jeffrey Gershenwald, Jonathan Salo, Barbara Pockaj, Richard Essner, Mark Faries, Kim Charney, Eli Avisar, Axel Hauschild, Friederike Egberts, Bruce Averbook, Carlos Garberoglio, John Vetto, Merrick Ross, David Chu, Vijay Trisal, Harald Hoekstra, Eric Whitman, Harold Wanebo, Daniel DeBonis, Michael Vezeridis, Aaron Chevinsky, Mohammed Kashani-Sabet, Yu Shyr, Lynne Berry, Zhiguo Zhao, Seng-jaw Soong, Stanley Leong] Background: Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database. Methods: Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed. Results: Of 3445 analyzable patients, 561 (16.3%) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN. Conclusions: These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk. Society of Surgical Oncology, 2011 White Jr. Richard Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA aut Ayers Gregory Vanderbilt University School of Medicine, Nashville, TN, USA aut Stell Virginia Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA aut Ding Shouluan University of Alabama at Birmingham, Birmingham, AL, USA aut Gershenwald Jeffrey University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Salo Jonathan Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA aut Pockaj Barbara Mayo Clinic, Scottsdale, AZ, USA aut Essner Richard John Wayne Cancer Institute, Santa Monica, CA, USA aut Faries Mark John Wayne Cancer Institute, Santa Monica, CA, USA aut Charney Kim St. Joseph Hospital, Orange, CA, USA aut Avisar Eli Miller School of Medicine, University of Miami, Miami, FL, USA aut Hauschild Axel University of Kiel, Kiel, Germany aut Egberts Friederike University of Kiel, Kiel, Germany aut Averbook Bruce MetroHealth Medical Center, Cleveland, OH, USA aut Garberoglio Carlos Loma Linda University Medical Center, Loma Linda, CA, USA aut Vetto John Oregon Health & Science University, Portland, OR, USA aut Ross Merrick University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut Chu David City of Hope Medical Center, Duarte, CA, USA aut Trisal Vijay City of Hope Medical Center, Duarte, CA, USA aut Hoekstra Harald Groningen University Medical Center, Groningen, The Netherlands aut Whitman Eric Atlantic Melanoma Center, Atlantic Health, Morristown, NJ, USA aut Wanebo Harold Roger Williams Medical Center, Providence, RI, USA aut DeBonis Daniel University of Buenos Aires, Buenos Aires, Argentina aut Vezeridis Michael Rhode Island Hospital, Providence, RI, USA aut Chevinsky Aaron Morristown Memorial Hospital, Morristown, NJ, USA aut Kashani-Sabet Mohammed California Pacific Medical Center and Research Institute, San Francisco, CA, USA aut Shyr Yu Vanderbilt University School of Medicine, Nashville, TN, USA aut Berry Lynne Vanderbilt University School of Medicine, Nashville, TN, USA aut Zhao Zhiguo Vanderbilt University School of Medicine, Nashville, TN, USA aut Soong Seng-jaw University of Alabama at Birmingham, Birmingham, AL, USA aut Leong Stanley California Pacific Medical Center and Research Institute, San Francisco, CA, USA aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3593-3600 1068-9265 18:13<3593 2011 18 10434 https://doi.org/10.1245/s10434-011-1826-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1826-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- White Jr Richard Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA aut NATIONALLICENCE 700 1- Ayers Gregory Vanderbilt University School of Medicine, Nashville, TN, USA aut NATIONALLICENCE 700 1- Stell Virginia Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA aut NATIONALLICENCE 700 1- Ding Shouluan University of Alabama at Birmingham, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Gershenwald Jeffrey University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Salo Jonathan Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA aut NATIONALLICENCE 700 1- Pockaj Barbara Mayo Clinic, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Essner Richard John Wayne Cancer Institute, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Faries Mark John Wayne Cancer Institute, Santa Monica, CA, USA aut NATIONALLICENCE 700 1- Charney Kim St. Joseph Hospital, Orange, CA, USA aut NATIONALLICENCE 700 1- Avisar Eli Miller School of Medicine, University of Miami, Miami, FL, USA aut NATIONALLICENCE 700 1- Hauschild Axel University of Kiel, Kiel, Germany aut NATIONALLICENCE 700 1- Egberts Friederike University of Kiel, Kiel, Germany aut NATIONALLICENCE 700 1- Averbook Bruce MetroHealth Medical Center, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Garberoglio Carlos Loma Linda University Medical Center, Loma Linda, CA, USA aut NATIONALLICENCE 700 1- Vetto John Oregon Health & Science University, Portland, OR, USA aut NATIONALLICENCE 700 1- Ross Merrick University of Texas M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Chu David City of Hope Medical Center, Duarte, CA, USA aut NATIONALLICENCE 700 1- Trisal Vijay City of Hope Medical Center, Duarte, CA, USA aut NATIONALLICENCE 700 1- Hoekstra Harald Groningen University Medical Center, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Whitman Eric Atlantic Melanoma Center, Atlantic Health, Morristown, NJ, USA aut NATIONALLICENCE 700 1- Wanebo Harold Roger Williams Medical Center, Providence, RI, USA aut NATIONALLICENCE 700 1- DeBonis Daniel University of Buenos Aires, Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Vezeridis Michael Rhode Island Hospital, Providence, RI, USA aut NATIONALLICENCE 700 1- Chevinsky Aaron Morristown Memorial Hospital, Morristown, NJ, USA aut NATIONALLICENCE 700 1- Kashani-Sabet Mohammed California Pacific Medical Center and Research Institute, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Shyr Yu Vanderbilt University School of Medicine, Nashville, TN, USA aut NATIONALLICENCE 700 1- Berry Lynne Vanderbilt University School of Medicine, Nashville, TN, USA aut NATIONALLICENCE 700 1- Zhao Zhiguo Vanderbilt University School of Medicine, Nashville, TN, USA aut NATIONALLICENCE 700 1- Soong Seng-jaw University of Alabama at Birmingham, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Leong Stanley California Pacific Medical Center and Research Institute, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3593-3600 1068-9265 18:13<3593 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer