caa a22 4500 445338644 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1781-5 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1781-5 Both BRAF V600E Mutation and Older Age (≥65Years) are Associated with Recurrent Papillary Thyroid Cancer [Elektronische Daten] [Gina Howell, Sally Carty, Michaele Armstrong, Shane LeBeau, Steven Hodak, Christopher Coyne, Michael Stang, Kelly McCoy, Marina Nikiforova, Yuri Nikiforov, Linwah Yip] Purpose: This study was designed to examine the aggressive features of BRAF-positive papillary thyroid cancer (PTC) and association with age. Methods: We compared the clinicopathologic parameters and BRAF V600E mutation status of 121 elderly (age ≥65years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age <65years) PTC patients. Results: Younger and elderly PTC patients had similar incidences of BRAF-positive tumors (41% vs. 38%; p=0.67). The elderly cohort was more likely to have smaller tumors (mean 1.6 vs. 2.1cm; p=0.001), present with advanced TNM stage (36% vs. 19%; p=0.008), and have persistent/recurrent disease (10% vs. 1%; p=0.006). BRAF-positive status was associated with PTC that were tall cell variant (p<0.001), had extrathyroidal extension (p<0.001), lymph node involvement (p=0.008), advanced (III/IV) TNM stage (p<0.001), and disease recurrence (p<0.001). Except for lymph node involvement, the association between aggressive histology characteristics at presentation and BRAF-positive PTC also was observed within the age-defined cohorts. In short-term follow-up (mean, 18months), persistent/recurrent PTC was much more likely to occur in patients who were both BRAF-positive and elderly (22%). Conclusions: BRAF mutations are equally present in younger and older patients. Aggressive histology characteristics at presentation are associated with BRAF-positive PTC, irrespective of age. However, the well-established association of BRAF with recurrence is limited to older (age ≥65years) patients. Society of Surgical Oncology, 2011 Howell Gina Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut Carty Sally Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut Armstrong Michaele Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut LeBeau Shane Department of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA aut Hodak Steven Department of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA aut Coyne Christopher Department of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA aut Stang Michael Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut McCoy Kelly Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut Nikiforova Marina Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA aut Nikiforov Yuri Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA aut Yip Linwah Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3566-3571 1068-9265 18:13<3566 2011 18 10434 https://doi.org/10.1245/s10434-011-1781-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1781-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Howell Gina Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Carty Sally Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Armstrong Michaele Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- LeBeau Shane Department of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Hodak Steven Department of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Coyne Christopher Department of Endocrinology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Stang Michael Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- McCoy Kelly Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Nikiforova Marina Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Nikiforov Yuri Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Yip Linwah Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3566-3571 1068-9265 18:13<3566 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer