caa a22 4500 445338652 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1824-y doi (NATIONALLICENCE)springer-10.1245/s10434-011-1824-y Oncologic Outcomes and Survival in pT0 Tumors After Radical Cystectomy in Patients Without Neoadjuvant Chemotherapy: Results from a Large Multicentre Collaborative Study [Elektronische Daten] [Morgan Rouprêt, Sarah Drouin, Stéphane Larré, Yann Neuzillet, Henry Botto, Maryam Hitier, Jerome Rigaud, Jeremy Crew, Evanguelos Xylinas, Laurent Salomon, Jean-Nicolas Cornu, François Iborra, Denis Champetier, François Rozet, Vincent Flamand, Cyrille Bastide, Luc Cormier, Xavier Durand, Pierre Lunardi, Pascal Rischmann, François-Xavier Nouhaud, Sophie Ferlicot, Jean-Jacques Patard, Aurélie Floch, Jacques Irani, Benoit Peyronnet, Karim Bensalah, Laura Poissonnier, Pascale Grès, Stéphane Droupy, Julien Casenave, Hervé Wallerand, Michel Soulié, Christian Pfister] Purpose: To assess the postsurgical survival of patients with urothelial carcinoma of the bladder with pT0 tumor at pathologic examination of cystectomy specimens. Methods: A multi-institutional, retrospective database was analyzed with data from 4758 radical cystectomy (RC) patients who underwent RC without neoadjuvant chemotherapy and who were diagnosed with pT0 on the basis of the pathologic specimen. Survival curves were estimated. A multivariate Cox model was used to evaluate the association between prognosis factors and disease recurrence or survival. Results: Overall, 258 patients (5.4%) were included in the study. The median age was 64years. At last resection, 171 tumors were invasive (at least pT2), and 87 were not. Median follow-up was 51months. At multivariate analysis, initial location of the tumor and absence of lymphadenectomy were associated with tumor recurrence (P=0.03 and P=0.005, respectively) and specific mortality (P=0.005 and 0.001, respectively). The main limitation of the study is its retrospective design, which is due to the rarity of this situation. Cancer-specific and recurrence-free survival rates were 89 and 85%, respectively, at 5years and 82 and 80%, respectively, at 10years. Conclusions: Despite acceptable oncological outcomes, patients with a pT0 tumor at the time of RC are still at risk of recurrence and progression and should not be considered to be entirely cured. In this population, stringent follow-up according to current recommendations should be effective. Society of Surgical Oncology, 2011 Rouprêt Morgan Academic Department of Urology of la Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France aut Drouin Sarah Academic Department of Urology of la Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France aut Larré Stéphane Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom aut Neuzillet Yann Department of Urology, Foch Hospital, University of Paris-Ile de France Ouest, Suresnes, France aut Botto Henry Department of Urology, Foch Hospital, University of Paris-Ile de France Ouest, Suresnes, France aut Hitier Maryam Academic Department of Urology, CHU Nantes, University of Nantes, Nantes, France aut Rigaud Jerome Academic Department of Urology, CHU Nantes, University of Nantes, Nantes, France aut Crew Jeremy Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom aut Xylinas Evanguelos Academic Department of Urology of Mondor Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris XII, Creteil, France aut Salomon Laurent Academic Department of Urology of Mondor Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris XII, Creteil, France aut Cornu Jean-Nicolas Academic Department of Urology of Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France aut Iborra François Department of Urology, Montpellier University, Montpellier, France aut Champetier Denis Academic Department of Urology, Lyon Sud Hospital, Claude Bernard Lyon 1 University, Lyon, France aut Rozet François Institut Mutualiste Montsouris, Paris, France aut Flamand Vincent Academic Department of Urology, CHRU Huriez Lille, University of Lille, Lille, France aut Bastide Cyrille Academic Department of Urology, Hospital Nord, University of Marseille, Marseille, France aut Cormier Luc Academic Department of Urology, CHRU Dijon, University of Dijon, Dijon, France aut Durand Xavier Department of Urology, Val de Grâce Military Hospital, Paris, France aut Lunardi Pierre Academic Department of Urology, CHU Toulouse, University of Toulouse, Toulouse, France aut Rischmann Pascal Academic Department of Urology, CHU Toulouse, University of Toulouse, Toulouse, France aut Nouhaud François-Xavier Academic Department of Urology, CHRU Rouen, University of Rouen, Rouen, France aut Ferlicot Sophie Academic Department of Urology of Kremlin-Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, University Paris XI, Paris, France aut Patard Jean-Jacques Academic Department of Urology of Kremlin-Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, University Paris XI, Paris, France aut Floch Aurélie Academic Department of Urology, CHRU Poitiers, University of Poitiers, Poitiers, France aut Irani Jacques Academic Department of Urology, CHRU Poitiers, University of Poitiers, Poitiers, France aut Peyronnet Benoit Academic Department of Urology, CHRU Rennes, University of Rennes, Rennes, France aut Bensalah Karim Academic Department of Urology, CHRU Rennes, University of Rennes, Rennes, France aut Poissonnier Laura Academic Department of Urology, Edouard Herriot Hospital, Claude Bernard Lyon 1 University, Lyon, France aut Grès Pascale Academic Department of Urology, CHRU Nimes, University of Nimes-Montpelliers, Nimes, France aut Droupy Stéphane Academic Department of Urology, CHRU Nimes, University of Nimes-Montpelliers, Nimes, France aut Casenave Julien Academic Department of Urology, Bordeaux Hospital, Bordeaux University, Bordeaux, France aut Wallerand Hervé Academic Department of Urology, Bordeaux Hospital, Bordeaux University, Bordeaux, France aut Soulié Michel Academic Department of Urology, CHU Toulouse, University of Toulouse, Toulouse, France aut Pfister Christian Academic Department of Urology, CHRU Rouen, University of Rouen, Rouen, France aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3833-3838 1068-9265 18:13<3833 2011 18 10434 https://doi.org/10.1245/s10434-011-1824-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1824-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rouprêt Morgan Academic Department of Urology of la Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France aut NATIONALLICENCE 700 1- Drouin Sarah Academic Department of Urology of la Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France aut NATIONALLICENCE 700 1- Larré Stéphane Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom aut NATIONALLICENCE 700 1- Neuzillet Yann Department of Urology, Foch Hospital, University of Paris-Ile de France Ouest, Suresnes, France aut NATIONALLICENCE 700 1- Botto Henry Department of Urology, Foch Hospital, University of Paris-Ile de France Ouest, Suresnes, France aut NATIONALLICENCE 700 1- Hitier Maryam Academic Department of Urology, CHU Nantes, University of Nantes, Nantes, France aut NATIONALLICENCE 700 1- Rigaud Jerome Academic Department of Urology, CHU Nantes, University of Nantes, Nantes, France aut NATIONALLICENCE 700 1- Crew Jeremy Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom aut NATIONALLICENCE 700 1- Xylinas Evanguelos Academic Department of Urology of Mondor Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris XII, Creteil, France aut NATIONALLICENCE 700 1- Salomon Laurent Academic Department of Urology of Mondor Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris XII, Creteil, France aut NATIONALLICENCE 700 1- Cornu Jean-Nicolas Academic Department of Urology of Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France aut NATIONALLICENCE 700 1- Iborra François Department of Urology, Montpellier University, Montpellier, France aut NATIONALLICENCE 700 1- Champetier Denis Academic Department of Urology, Lyon Sud Hospital, Claude Bernard Lyon 1 University, Lyon, France aut NATIONALLICENCE 700 1- Rozet François Institut Mutualiste Montsouris, Paris, France aut NATIONALLICENCE 700 1- Flamand Vincent Academic Department of Urology, CHRU Huriez Lille, University of Lille, Lille, France aut NATIONALLICENCE 700 1- Bastide Cyrille Academic Department of Urology, Hospital Nord, University of Marseille, Marseille, France aut NATIONALLICENCE 700 1- Cormier Luc Academic Department of Urology, CHRU Dijon, University of Dijon, Dijon, France aut NATIONALLICENCE 700 1- Durand Xavier Department of Urology, Val de Grâce Military Hospital, Paris, France aut NATIONALLICENCE 700 1- Lunardi Pierre Academic Department of Urology, CHU Toulouse, University of Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Rischmann Pascal Academic Department of Urology, CHU Toulouse, University of Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Nouhaud François-Xavier Academic Department of Urology, CHRU Rouen, University of Rouen, Rouen, France aut NATIONALLICENCE 700 1- Ferlicot Sophie Academic Department of Urology of Kremlin-Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, University Paris XI, Paris, France aut NATIONALLICENCE 700 1- Patard Jean-Jacques Academic Department of Urology of Kremlin-Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, University Paris XI, Paris, France aut NATIONALLICENCE 700 1- Floch Aurélie Academic Department of Urology, CHRU Poitiers, University of Poitiers, Poitiers, France aut NATIONALLICENCE 700 1- Irani Jacques Academic Department of Urology, CHRU Poitiers, University of Poitiers, Poitiers, France aut NATIONALLICENCE 700 1- Peyronnet Benoit Academic Department of Urology, CHRU Rennes, University of Rennes, Rennes, France aut NATIONALLICENCE 700 1- Bensalah Karim Academic Department of Urology, CHRU Rennes, University of Rennes, Rennes, France aut NATIONALLICENCE 700 1- Poissonnier Laura Academic Department of Urology, Edouard Herriot Hospital, Claude Bernard Lyon 1 University, Lyon, France aut NATIONALLICENCE 700 1- Grès Pascale Academic Department of Urology, CHRU Nimes, University of Nimes-Montpelliers, Nimes, France aut NATIONALLICENCE 700 1- Droupy Stéphane Academic Department of Urology, CHRU Nimes, University of Nimes-Montpelliers, Nimes, France aut NATIONALLICENCE 700 1- Casenave Julien Academic Department of Urology, Bordeaux Hospital, Bordeaux University, Bordeaux, France aut NATIONALLICENCE 700 1- Wallerand Hervé Academic Department of Urology, Bordeaux Hospital, Bordeaux University, Bordeaux, France aut NATIONALLICENCE 700 1- Soulié Michel Academic Department of Urology, CHU Toulouse, University of Toulouse, Toulouse, France aut NATIONALLICENCE 700 1- Pfister Christian Academic Department of Urology, CHRU Rouen, University of Rouen, Rouen, France aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3833-3838 1068-9265 18:13<3833 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer