caa a22 4500 445338717 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1790-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1790-4 Significance of Perineural Invasion, Lymphovascular Invasion, and High-Grade Prostatic Intraepithelial Neoplasia in Robot-Assisted Laparoscopic Radical Prostatectomy [Elektronische Daten] [Jae Jung, Jae Lee, Francis Arkoncel, Nam Cho, Noor Yusoff, Kwang Kim, Jae Song, Sung Kim, Koon Rha] Background: Recently, more detailed histopathological variables such as perineural invasion (PNI), lymphovascular invasion (LVI), and high-grade prostatic intraepithelial neoplasia (HGPIN) have been investigated as prognostic factors for adverse pathologic findings on the radical prostatectomy specimen. We aim to determine whether these pathological factors are associated with adverse pathologic features after robot-assisted laparoscopic radical prostatectomy (RALP). Methods: All 407 patients who underwent RALP with pelvic lymphadenectomy between July 2005 and December 2009 were analyzed, retrospectively. We investigated the association of these three pathological parameters with adverse pathological findings in RALP specimen and biochemical recurrence using Kaplan-Meier analysis with log-rank test and a multivariate Cox proportional hazard model. Results: The PNI and LVI were significantly associated with a higher pathological stage, a higher pathological Gleason score, a higher tumor volume in RALP specimen, a higher frequency of positive surgical margins, and a higher frequency of seminal vesicle invasion. In addition, PNI correlated with preoperative PSA, clinical stage, and Gleason score on needle biopsy. However, the HGPIN was not significantly associated with the clinicopathological characteristics studied. Using log-rank test, presence of PNI (P<0.001) increases the probability of biochemical recurrence. On multivariate analysis, all three pathological parameters were not significantly correlated with biochemical recurrence. Conclusion: Although presence of PNI and LVI in RALP specimen correlated with multiple adverse clinicopathological factors, it did not predict biochemical recurrence, thus limiting its clinical usefulness. HGPIN was not significantly associated with the clinicopathological characteristics studied. Society of Surgical Oncology, 2011 Jung Jae Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut Lee Jae Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut Arkoncel Francis Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut Cho Nam Department of Pathology, Yonsei University College of Medicine, Seoul, Korea aut Yusoff Noor Institute of Urology and Nephrology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia aut Kim Kwang Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut Song Jae Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut Kim Sung Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut Rha Koon Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3828-3832 1068-9265 18:13<3828 2011 18 10434 https://doi.org/10.1245/s10434-011-1790-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1790-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jung Jae Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut NATIONALLICENCE 700 1- Lee Jae Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Arkoncel Francis Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Nam Department of Pathology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Yusoff Noor Institute of Urology and Nephrology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Kim Kwang Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut NATIONALLICENCE 700 1- Song Jae Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut NATIONALLICENCE 700 1- Kim Sung Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea aut NATIONALLICENCE 700 1- Rha Koon Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3828-3832 1068-9265 18:13<3828 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer