caa a22 4500 445338733 CHVBK 20180317142804.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1769-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1769-1 Splenic Artery Invasion in Pancreatic Adenocarcinoma of the Body and Tail: A Novel Prognostic Parameter for Patient Selection [Elektronische Daten] [Stefano Partelli, Stefano Crippa, Giuliano Barugola, Domenico Tamburrino, Paola Capelli, Mirko D'Onofrio, Paolo Pederzoli, Massimo Falconi] Background: The value of splenic vessels invasion (which identified T3 tumors) in prognosis after resection for pancreatic ductal adenocarcinoma (PDA) of the body and tail has not been extensively investigated. The goal of this study was to evaluate prognostic factors in PDA of the body/tail, emphasizing the role of splenic vessels infiltration. Methods: Between 1990 and 2008, 87 patients who underwent distal pancreatectomy (DP) for histologically proven PDA of the body and tail were analyzed. Clinicopathological prognostic factors for survival were evaluated. Univariate and multivariable analyses were performed. Results: Postoperative morbidity was 31% with no mortality. The 1-, 3-, and 5-year overall survival rates were 77%, 48%, and 24.5%, respectively. Invasion of the splenic artery (SA) was observed in 19 patients (22%). Patients with SA invasion had a significantly poorer prognosis compared with those without SA invasion (median survival: 15 vs. 39months, P=0.014). On multivariable analysis, adjuvant therapy, poor differentiation (G3/G4), R2 resection, the presence of lymph node metastases, and SA invasion were independent predictors of survival. Conclusions: Along with other well-known prognostic factors, invasion of SA is an independent predictor of poor survival in PDA of the body/tail. In case of the presence of SA infiltration, neoadjuvant treatment should be considered. SA infiltration might be reclassified from a T3 to T4 tumor. Society of Surgical Oncology, 2011 Partelli Stefano Department of Surgery, University of Verona, Verona, Italy aut Crippa Stefano Department of Surgery, University of Verona, Verona, Italy aut Barugola Giuliano Department of Surgery, University of Verona, Verona, Italy aut Tamburrino Domenico Department of Surgery, University of Verona, Verona, Italy aut Capelli Paola Department of Pathology, University of Verona, Verona, Italy aut D'Onofrio Mirko Department of Radiology, University of Verona, Verona, Italy aut Pederzoli Paolo Department of Surgery, University of Verona, Verona, Italy aut Falconi Massimo Department of Surgery, University of Verona, Verona, Italy aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3608-3614 1068-9265 18:13<3608 2011 18 10434 https://doi.org/10.1245/s10434-011-1769-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1769-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Partelli Stefano Department of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Crippa Stefano Department of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Barugola Giuliano Department of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Tamburrino Domenico Department of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Capelli Paola Department of Pathology, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- D'Onofrio Mirko Department of Radiology, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Pederzoli Paolo Department of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 700 1- Falconi Massimo Department of Surgery, University of Verona, Verona, Italy aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3608-3614 1068-9265 18:13<3608 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer