caa a22 4500 44533875X CHVBK 20180317142804.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1793-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1793-1 Survival and Quality of Life Following Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Colonic Origin [Elektronische Daten] [Adrienne Hill, Richard McQuellon, Gregory Russell, Perry Shen, John Stewart IV, Edward Levine] Background: Peritoneal carcinomatosis of colonic origin (PCC) is a life-threatening diagnosis. Cytoreductive surgery (CS) with hyperthermic intraperitoneal chemotherapy (HIPEC) offers patients the prospect of long-term survival with alleviation of symptoms. Methods: Patients underwent HIPEC for PCC and completed questionnaires preoperatively (T1) and after surgery at 3 (T2), 6 (T3), and 12 (T4) months. Questionnaires included the Functional Assessment of Cancer Therapy—Colon (FACT-C), Brief Pain Inventory (BPI), SF-36 Medical Outcomes Study Survey (SF-36), Center for Epidemiologic Studies—Depression Scale (CES-D), and the ECOG Performance Status Rating. Results: A total of 62 patients were assessed before surgery. Median overall survival was 18months, with 71.3±6.3% survival at 1year. Emotional well-being (P=.0007) improved after HIPEC. Social/family well-being (P=.065) and the colon subscale (P=.061) of the FACT worsened at T2, but recovered by T3. One-third to one-half of patients reported depressive symptoms over the course of the study. Pain scores increased above BL at T2, but decreased below BL at T3 and T4. Conclusions: Emotional well being is improved after CS+HIPEC despite complications that may affect short-term recovery. Most patients remaining in the study recover to preoperative levels of functioning between 3 and 6months after surgery. For some, survival can be attained without major decrement in QOL at 1year. QOL concerns must be a key component in the evaluation for patients with PCC for CS and HIPEC. Society of Surgical Oncology, 2011 Hill Adrienne Section of Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut McQuellon Richard Section of Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut Russell Gregory Biostatistical Sciences, Section of Biostatistics, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut Shen Perry Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut Stewart IV John Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut Levine Edward Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3673-3679 1068-9265 18:13<3673 2011 18 10434 https://doi.org/10.1245/s10434-011-1793-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1793-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hill Adrienne Section of Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- McQuellon Richard Section of Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Russell Gregory Biostatistical Sciences, Section of Biostatistics, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Shen Perry Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Stewart IV John Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Levine Edward Surgical Oncology Service, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3673-3679 1068-9265 18:13<3673 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer