caa a22 4500 445338792 CHVBK 20180317142805.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1777-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1777-1 Risk Factors for Nonsynchronous Second Primary Malignancy and Related Death in Patients with Differentiated Thyroid Carcinoma [Elektronische Daten] [Brian Lang, Kai Wong] Background: Differentiated thyroid cancer (DTC) survivors are at increased risk of developing nonsynchronous second primary malignancy (NSPM). This study aims to examine possible risk factors leading to occurrence of NSPM as well as risk factors leading to NSPM-related death in patients with DTC. Methods: Of the 1,106 patients with DTC managed at our institution, 92 (8.3%) patients developed NSPM and 40 (3.6%) patients died of NSPM. All causes of death were confirmed by medical record, autopsy report or death certificate. Clinicopathological variables were compared between those without NSPM and with NSPM as well as between those who died of NSPM and did not die of NSPM. Significant variables on univariate analysis were entered into a Cox proportional hazards model. Results: The median latency period from diagnosis of DTC to NSPM was 142.7 (range 16.8-511.0) months. For occurrence of NSPM, age at DTC diagnosis ≥50years old [relative risk (RR)=2.35], cumulative radioactive iodine (RAI) activity 3.0-8.9GBq (RR=2.38), and external local radiotherapy (ERT) (RR=1.95) were significant risk factors. For NSPM-related death, age at DTC diagnosis ≥50years old (RR=3.32) and nonbreast cancer (RR=5.76) were significant risk factors. Conclusions: NSPM accounted for 18.7% of all deaths in DTC, but mortality was high (43.5%). Age at DTC diagnosis ≥50years old, cumulative RAI activity 3.0-8.9GBq, and ERT were significant risk factors for occurrence of NSPM, whereas age at DTC diagnosis ≥50years old and the diagnosis of nonbreast cancer were significant risk factors for NSPM-related death. The Author(s), 2011 Lang Brian Division of Endocrine Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China aut Wong Kai Division of Endocrine Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3559-3565 1068-9265 18:13<3559 2011 18 10434 https://doi.org/10.1245/s10434-011-1777-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1777-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lang Brian Division of Endocrine Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 700 1- Wong Kai Division of Endocrine Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3559-3565 1068-9265 18:13<3559 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer