caa a22 4500 445338865 CHVBK 20180317142805.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1830-0 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1830-0 Is Neo-adjuvant Chemotherapy a "Waiver” of Extensive Upper Abdominal Surgery in Advanced Epithelial Ovarian Cancer? [Elektronische Daten] [Sokbom Kang, Yoo Jong, Jong Hwang, Myong Lim, Sang-Soo Seo, Chong-Woo Yoo, Sang-Yoon Park] Background: The goal of this study was to explore the necessity of extensive surgical procedures in patients who received neoadjuvant chemotherapy (NAC). Methods: We analyzed the surgical outcomes and frequency of extensive procedures required for maximal cytoreductive surgery after NAC and primary debulking surgery (PDS) in 256 women with advanced epithelial ovarian cancer. Results: NAC was performed in 116 of 256 women (45.3%). In NAC group, complete cytoreduction rate and optimal cytoreduction rate were 60.3 and 92.2%, respectively. Although the NAC group comprised patients with higher risk of suboptimal cytoreduction, complete cytoreduction rate was similar to that of PDS group (57.9%, P=.69). Moreover, blood loss and surgical complexity significantly reduced in NAC group (P=.011 and .017). Extensive upper abdominal surgery (EUAS) was performed in 70 of 116 patients (60.3%) in the NAC group. The frequency of EUAS was similar between NAC and PDS group (P=.60). Among NAC group, gross upper abdominal metastasis requiring EUAS was found in 51 patients (44%, 95% confidence interval=35.3-53.1%). Conclusions: A significant proportion of patients who received NAC still have gross metastatic tumors requiring EUAS. Gynecologic oncologists should be familiar with EUAS and be ready to perform any required procedures together with multidisciplinary teams, even in the patients who have received NAC. Society of Surgical Oncology, 2011 Kang Sokbom Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Jong Yoo Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Hwang Jong Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Lim Myong Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Seo Sang-Soo Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Yoo Chong-Woo Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Park Sang-Yoon Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3824-3827 1068-9265 18:13<3824 2011 18 10434 https://doi.org/10.1245/s10434-011-1830-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1830-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kang Sokbom Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 700 1- Jong Yoo Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 700 1- Hwang Jong Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 700 1- Lim Myong Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 700 1- Seo Sang-Soo Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 700 1- Yoo Chong-Woo Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 700 1- Park Sang-Yoon Gynecologic Oncology Research Division, Uterine Cancer Center, National Cancer Center, Goyang, Republic of Korea aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3824-3827 1068-9265 18:13<3824 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer