caa a22 4500 445338938 CHVBK 20180317142805.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1818-9 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1818-9 Features Associated with Successful Recruitment of Diverse Patients onto Cancer Clinical Trials: Report from the American College of Surgeons Oncology Group [Elektronische Daten] [Kathleen Diehl, Erin Green, Armin Weinberg, Wayne Frederick, Dennis Holmes, Bettye Green, Arden Morris, Henry Kuerer, Robert Beltran, Jane Mendez, Venus Gines, David Ota, Heidi Nelson, Lisa Newman] Background: The clinical trials mechanism of standardized treatment and follow-up for cancer patients with similar stages and patterns of disease is the most powerful approach available for evaluating the efficacy of novel therapies, and clinical trial participation should protect against delivery of care variations associated with racial/ethnic identity and/or socioeconomic status. Unfortunately, disparities in clinical trial accrual persist, with African Americans (AA) and Hispanic/Latino Americans (HA) underrepresented in most studies. Study Design: We evaluated the accrual patterns for 10 clinical trials conducted by the American College of Surgeons Oncology Group (ACOSOG) 1999-2009, and analyzed results by race/ethnicity as well as by study design. Results: Eight of 10 protocols were successful in recruiting AA and/or HA participants; three of four randomized trials were successful. Features that were present among all of the successfully recruiting protocols were: (1) studies designed to recruit patients with regional or advanced-stage disease (2 of 2 protocols); and (2) studies that involved some investigational systemic therapy (3 of 3 protocols). Discussion: AA and HA cancer patients can be successfully accrued onto randomized clinical trials, but study design affects recruitment patterns. Increased socioeconomic disadvantages observed within minority-ethnicity communities results in barriers to screening and more advanced cancer stage distribution. Improving cancer early detection is critical in the effort to eliminate outcome disparities but existing differences in disease burden results in diminished eligibility for early-stage cancer clinical trials among minority-ethnicity patients. Society of Surgical Oncology, 2011 Diehl Kathleen Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA aut Green Erin Mayo Clinic, Rochester, MN, USA aut Weinberg Armin Baylor Medical College, Houston, TX, USA aut Frederick Wayne Howard University, Washington, DC, USA aut Holmes Dennis Department of Breast Surgery, USC Norris Cancer Center, Los Angeles, CA, USA aut Green Bettye ACOSOG Patient Advocate Committee, c/o American College of Surgeons Oncology Group, Durham, NC, USA aut Morris Arden Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA aut Kuerer Henry Department of Surgical Oncology, UTMD Anderson Cancer Center, Houston, TX, USA aut Beltran Robert Latino Med Policy Institute, Los Alamitos, CA, USA aut Mendez Jane School of Medicine, Department of Surgery, Boston University, Boston, MA, USA aut Gines Venus ACOSOG Special Populations Committee, c/o American College of Surgeons Oncology Group, Durham, NC, USA aut Ota David Department of Surgery, Duke University, Durham, NC, USA aut Nelson Heidi Mayo Clinic, Rochester, MN, USA aut Newman Lisa Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3544-3550 1068-9265 18:13<3544 2011 18 10434 https://doi.org/10.1245/s10434-011-1818-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1818-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Diehl Kathleen Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Green Erin Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Weinberg Armin Baylor Medical College, Houston, TX, USA aut NATIONALLICENCE 700 1- Frederick Wayne Howard University, Washington, DC, USA aut NATIONALLICENCE 700 1- Holmes Dennis Department of Breast Surgery, USC Norris Cancer Center, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Green Bettye ACOSOG Patient Advocate Committee, c/o American College of Surgeons Oncology Group, Durham, NC, USA aut NATIONALLICENCE 700 1- Morris Arden Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Kuerer Henry Department of Surgical Oncology, UTMD Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Beltran Robert Latino Med Policy Institute, Los Alamitos, CA, USA aut NATIONALLICENCE 700 1- Mendez Jane School of Medicine, Department of Surgery, Boston University, Boston, MA, USA aut NATIONALLICENCE 700 1- Gines Venus ACOSOG Special Populations Committee, c/o American College of Surgeons Oncology Group, Durham, NC, USA aut NATIONALLICENCE 700 1- Ota David Department of Surgery, Duke University, Durham, NC, USA aut NATIONALLICENCE 700 1- Nelson Heidi Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Newman Lisa Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3544-3550 1068-9265 18:13<3544 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer