caa a22 4500 445338954 CHVBK 20180317142805.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1762-8 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1762-8 Viable Tumor Tissue Adherent to Needle Applicators after Local Ablation: A Risk Factor for Local Tumor Progression [Elektronische Daten] [Nikol Snoeren, Joost Huiskens, Arjen Rijken, Richard van Hillegersberg, Arian van Erkel, Gerrit Slooter, Joost Klaase, Petrousjka van den Tol, Fibo Ten Kate, Maarten Jansen, Thomas van Gulik] Background: Local tumor progression (LTP) is a serious complication after local ablation of malignant liver tumors, negatively influencing patient survival. LTP may be the result of incomplete ablation of the treated tumor. In this study, we determined whether viable tumor cells attached to the needle applicator after ablation was associated with LTP and disease-free survival. Methods: In this prospective study, tissue was collected of 96 consecutive patients who underwent local liver ablations for 130 liver malignancies. Cells and tissue attached to the needle applicators were analyzed for viability using glucose-6-phosphate-dehydrogenase staining and autofluorescence intensity levels of H&E stained sections. Patients were followed-up until disease progression. Results: Viable tumor cells were found on the needle applicators after local ablation in 26.7% of patients. The type of needle applicator used, an open approach, and the omission of track ablation were significantly correlated with viable tumor tissue adherent to the needle applicator. The presence of viable cells was an independent predictor of LTP. The attachment of viable cells to the needle applicators was associated with a shorter time to LTP. Conclusions: Viable tumor cells adherent to the needle applicators were found after ablation of 26.7% of patients. An independent risk factor for viable cells adherent to the needle applicators is the omission of track ablation. We recommend using only RFA devices that have track ablation functionality. Adherence of viable tumor cells to the needle applicator after local ablation was an independent risk factor for LTP. The Author(s), 2011 Snoeren Nikol University Medical Centre Utrecht, Utrecht, The Netherlands aut Huiskens Joost Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut Rijken Arjen Amphia Hospital, Breda, The Netherlands aut van Hillegersberg Richard University Medical Centre Utrecht, Utrecht, The Netherlands aut van Erkel Arian Leiden University Medical Centre, Leiden, The Netherlands aut Slooter Gerrit Maxima Medical Centre, Veldhoven, The Netherlands aut Klaase Joost Medisch Spectrum Twente, Enschede, Medisch Spectrum Twente aut van den Tol Petrousjka VU Medical Centre, Amsterdam, The Netherlands aut Ten Kate Fibo Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut Jansen Maarten Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut van Gulik Thomas Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3702-3710 1068-9265 18:13<3702 2011 18 10434 https://doi.org/10.1245/s10434-011-1762-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1762-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Snoeren Nikol University Medical Centre Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Huiskens Joost Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Rijken Arjen Amphia Hospital, Breda, The Netherlands aut NATIONALLICENCE 700 1- van Hillegersberg Richard University Medical Centre Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van Erkel Arian Leiden University Medical Centre, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Slooter Gerrit Maxima Medical Centre, Veldhoven, The Netherlands aut NATIONALLICENCE 700 1- Klaase Joost Medisch Spectrum Twente, Enschede, Medisch Spectrum Twente aut NATIONALLICENCE 700 1- van den Tol Petrousjka VU Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Ten Kate Fibo Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Jansen Maarten Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Gulik Thomas Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3702-3710 1068-9265 18:13<3702 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer