caa a22 4500 445338997 CHVBK 20180317142805.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1834-9 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1834-9 Safety of Thoracoscopic Lobectomy in Locally Advanced Lung Cancer [Elektronische Daten] [Mark Hennon, Rohit Sahai, Sai Yendamuri, Wei Tan, Todd Demmy, Chukwumere Nwogu] Background: Thoracoscopic lobectomy is well established for the treatment of early non-small cell lung cancer (NSCLC). Its safety and efficacy for advanced-stage disease remain uncertain. Methods: Between January 1, 2002, and July 31, 2007, a total of 125 patients were evaluated for thoracoscopic lobectomy for advanced NSCLC. Thoracoscopic lobectomy was completed in 73 patients. Eleven patients were excluded for extensive chest wall involvement. Open resection was performed in 41 patients, with 19 planned thoracotomies and 22 conversions from an initial thoracoscopic approach. Results: Median operative blood loss, operation time, major complications, and hospital length of stay were all similar for patients undergoing thoracoscopic and open resection. A higher percentage of patients who underwent thoracoscopic lobectomy were able to receive adjuvant therapy compared to the open group (37.2% vs. 5.2%; P=0.006). The differences between the thoracoscopic and open groups in overall survival (43.7 vs. 22.9months; P=0.59) and disease-free survival (34.7 vs. 16.7months; P=0.84) were not significant. Conclusions: Thoracoscopic lobectomy for advanced-stage NSCLC can be performed safely, with results equivalent to open techniques. With continued experience, lower morbidity with resections performed for advanced-stage disease by video-assisted thoracoscopic surgery will be expected, similar to that observed with early-stage disease. This is particularly important given the large number of frail patients with advanced-stage disease who require multimodal therapy. Society of Surgical Oncology, 2011 Hennon Mark Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut Sahai Rohit Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut Yendamuri Sai Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut Tan Wei Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY, USA aut Demmy Todd Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut Nwogu Chukwumere Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3732-3736 1068-9265 18:13<3732 2011 18 10434 https://doi.org/10.1245/s10434-011-1834-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1834-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hennon Mark Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Sahai Rohit Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Yendamuri Sai Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Tan Wei Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Demmy Todd Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Nwogu Chukwumere Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3732-3736 1068-9265 18:13<3732 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer