caa a22 4500 445339012 CHVBK 20180317142805.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1245/s10434-011-1831-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1831-z Efficacy of Surgical Microwave Therapy in Patients with Unresectable Hepatocellular Carcinoma [Elektronische Daten] [Shinji Itoh, Yasuharu Ikeda, Hirofumi Kawanaka, Toshirou Okuyama, Katsumi Kawasaki, Daihiko Eguchi, Daisuke Korenaga, Kenji Takenaka] Background: We aimed to evaluate the efficacy and long-term outcome in surgical microwave therapy (MW) for patients with unresectable hepatocellular carcinoma (HCC). Methods: An institutional review board approved and single-institutional study of surgical MW of unresectable HCC was conducted from May 2003 to December 2010. The median follow-up period was 19months (range 1-77months). Results: A total of 60 patients underwent 143 surgical MW for unresectable HCC. Of these, 15 patients had initial HCC and 45 had recurrent HCC. The median tumor size of HCC was 1.95cm (range 0.8-3.3cm). The median numbers of nodules that underwent surgical MW were 2 (range 1-9). Multinodular type was found in 33 patients (55%). Morbidity was 18.3%, and there was zero mortality. Also, 3 patients (5%) had incomplete MW. Of the 60 patients, 39 (65%) had recurrence, and 7 (11.6%) had local recurrence. The 1- and 3-year recurrence-free survival rates of the patients who underwent surgical MW for initial HCC were 55.1 and 36.7%, respectively, and those for recurrent HCC were 41.6% and 8.8%, respectively. A tumor size ≥2.0cm and multiple nodules were selected as independent and significant indicators for recurrence of the disease. The 1-, 3-, and 5-year overall survival rates after the surgical MW procedure were 93.9, 53.8, and 43.1%, respectively. A level of des-gamma carboxyprothrombin (DCP) was an independent and significant indicator for overall survival. Conclusions: Surgical MW is an effective method for treating initial or recurrent unresectable HCC, and it can be undergone safely. Society of Surgical Oncology, 2011 Itoh Shinji Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Ikeda Yasuharu Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Kawanaka Hirofumi Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Okuyama Toshirou Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Kawasaki Katsumi Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Eguchi Daihiko Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Korenaga Daisuke Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Takenaka Kenji Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3650-3656 1068-9265 18:13<3650 2011 18 10434 https://doi.org/10.1245/s10434-011-1831-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1831-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Shinji Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Ikeda Yasuharu Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kawanaka Hirofumi Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Okuyama Toshirou Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kawasaki Katsumi Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Eguchi Daihiko Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Korenaga Daisuke Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takenaka Kenji Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/13(2011-12-01), 3650-3656 1068-9265 18:13<3650 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer