caa a22 4500 445339136 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1963-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1963-1 Correlation of Ductal Lavage Cytology with Ductoscopy-Directed Duct Excision Histology in Women at High Risk for Developing Breast Cancer: A Prospective, Single-Institution Trial [Elektronische Daten] [Amy Cyr, Julie Margenthaler, Jill Conway, Antonella Rastelli, Rosa Davila, Feng Gao, Jill Dietz] Objectives: The study was designed to determine which histological lesions produce cellular atypia in lavage specimens and whether ductoscopy adds useful information for the evaluation of high-risk patients with atypical lavage cytology. Methods: We prospectively recruited women ≥35years at high risk for developing breast cancer. All underwent ductal lavage. Women found to have atypia underwent ductoscopy-directed duct excision (group 1). Women without atypia were observed (group 2). Data included patient demographics, risk assessment, cytologic and histologic findings, and outcomes. Descriptive statistics were utilized for data summary and were compared using Fisher's exact test. Results: We enrolled 102 women; 93 (91%) were Caucasian. Their median age was 49 (range 34-73) years with a median follow-up of 80 (range 5-90) months. Overall, 27 (26%) had atypical lavage cytology (group 1), and 75 (74%) had benign cytology (group 2). Subsequent duct excision in group 1 revealed benign histology in 11 (44%), papillomas in 9 (36%), atypical hyperplasia (AH) in 4 (16%), and ductal carcinoma in situ (DCIS) in 1 (4%). At follow-up, three patients developed breast cancer, including one group 1 patient and two group 2 patients. There were no differences between groups 1 and 2 according to patient demographics, Gail scores, or risk for subsequent breast cancer (P>0.05). Conclusions: Although 20% of high-risk women with ductal lavage atypia have AH or malignancy on subsequent excision, the majority do not. Atypia identified by ductal lavage is not associated with a higher risk of developing subsequent breast cancer, even in this high-risk population. Society of Surgical Oncology, 2011 Cyr Amy Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Margenthaler Julie Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Conway Jill Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Rastelli Antonella Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA aut Davila Rosa Department of Pathology, Missouri Baptist Medical Center, St. Louis, MO, USA aut Gao Feng Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA aut Dietz Jill Women's Health Institute, Cleveland Clinic Foundation, Cleveland, OH, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3192-3197 1068-9265 18:11<3192 2011 18 10434 https://doi.org/10.1245/s10434-011-1963-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1963-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cyr Amy Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Margenthaler Julie Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Conway Jill Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Rastelli Antonella Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Davila Rosa Department of Pathology, Missouri Baptist Medical Center, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Gao Feng Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Dietz Jill Women's Health Institute, Cleveland Clinic Foundation, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3192-3197 1068-9265 18:11<3192 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer