caa a22 4500 445339152 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-2009-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-2009-4 Mammography in 40-Year-Old Women: What Difference Does It Make? The Potential Impact of the U.S. Preventative Services Task Force (USPSTF) Mammography Guidelines [Elektronische Daten] [Nicole Shen, Linda Hammonds, Dick Madsen, Paul Dale] Background: This 10-year retrospective chart review evaluates the potential impact the most recent U.S. Preventative Services Task Force (USPSTF) report recommending against annual mammographic screening of women aged 40-49years. Methods: The medical record database was systematically searched to discover all women aged 40-49years treated for breast cancer over a 10-year period. These women were separated into 2 cohorts—mammographically detected cancer (MDC) and nonmammographically detected cancer (NMDC). Statistical analysis of the cohorts was performed for family history (FH), sentinel lymph node (SLN) status, tumor size at presentation, and disease-free and overall survival. Results: A total of 1581 women were treated for breast cancer; of these, 311 were between the ages of 40 and 49years with complete diagnostic information, 145 were MDC, and 166 were NMDC. The average tumor diameter of the MDC group was 20.68mm, which was significantly smaller than that of the NMDC group at 30.38mm (P<.0001). Women with MDC had a significantly lower incidence of SLN positive cancer than the NMDC group, 28 of 113 (24.78%) vs. 85 of 152 (55.92%; P<.0001), respectively. The 5-year disease-free survival for both groups was MDC 94% (95% confidence interval [95% CI], 87-97%) and NMDC 71% (95% CI 62-78%). The overall 5-year survival estimates were MDC 97% (95% CI 92-99%) and NMDC 78% (95% CI 69-85%), respectively. Conclusion: This review demonstrates the significance of mammographic screening for early detection and treatment of breast cancer. Mammographic screening in women aged 40-49 detected smaller tumors with less nodal metastasis, resulting in improved survival, which supports annual mammographic screening in this age group. Society of Surgical Oncology, 2011 Shen Nicole University of Missouri School of Medicine, Columbia, MO, USA aut Hammonds Linda Surgical Oncology, University of Missouri School of Medicine, Columbia, MO, USA aut Madsen Dick Biostatistics, University of Missouri School of Medicine, Columbia, MO, USA aut Dale Paul Surgical Oncology, University of Missouri School of Medicine, Columbia, MO, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3066-3071 1068-9265 18:11<3066 2011 18 10434 https://doi.org/10.1245/s10434-011-2009-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-2009-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shen Nicole University of Missouri School of Medicine, Columbia, MO, USA aut NATIONALLICENCE 700 1- Hammonds Linda Surgical Oncology, University of Missouri School of Medicine, Columbia, MO, USA aut NATIONALLICENCE 700 1- Madsen Dick Biostatistics, University of Missouri School of Medicine, Columbia, MO, USA aut NATIONALLICENCE 700 1- Dale Paul Surgical Oncology, University of Missouri School of Medicine, Columbia, MO, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3066-3071 1068-9265 18:11<3066 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer