caa a22 4500 445339195 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1957-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1957-z Distance of Breast Cancer From the Skin and Nipple Impacts Axillary Nodal Metastases [Elektronische Daten] [Bijan Ansari, Marilyn Morton, Darcy Adamczyk, Katie Jones, Julie Brodt, Amy Degnim, James Jakub, Christine Lohse, Judy Boughey] Background: Lymphatic drainage of the breast is via subareolar and dermal lymphatics. The aim of this study was to determine whether distance of breast cancers from the skin and/or distance from the nipple impacts the likelihood of axillary nodal metastases. Methods: A retrospective review was performed of sonographically visible T1 and T2 breast cancers with breast and axillary surgery performed at Mayo Clinic, Rochester, MN. Distance of tumor from the nipple was reviewed. Ultrasounds were reviewed to measure the distance of tumor from the skin. Results: Data were collected on 233 eligible T1 or T2 breast cancers, of which 177 (76%) were node negative and 56 (24%) were node positive. On multivariable analysis, tumor stage and lymphovascular invasion, as well as decreasing distance of the tumor from the nipple and decreasing distance of the tumor from the skin, were significantly associated with axillary lymph node positivity. Each 1-cm decrease in the distance of the tumor from the nipple was associated with a 23% increased likelihood of positive lymph nodes (odds ratio 1.23; P=.003). Each 1-mm decrease in the distance of the tumor from the skin was associated with a 15% increased likelihood of positive lymph nodes (odds ratio 1.15; P=.003). Conclusion: T1 and T2 breast cancers located closer to the skin and those located closer to the nipple have a higher incidence of metastases to axillary lymph nodes. Distance from the skin and distance from the nipple should be considered when estimating a patient's likelihood of axillary nodal positivity. Society of Surgical Oncology, 2011 Ansari Bijan Department of Surgery, Mayo Clinic, Rochester, MN, USA aut Morton Marilyn Division of Breast Imaging, Mayo Clinic, Rochester, MN, USA aut Adamczyk Darcy Division of Breast Imaging, Mayo Clinic, Rochester, MN, USA aut Jones Katie Division of Breast Imaging, Mayo Clinic, Rochester, MN, USA aut Brodt Julie Department of Surgery, Mayo Clinic, Rochester, MN, USA aut Degnim Amy Department of Surgery, Mayo Clinic, Rochester, MN, USA aut Jakub James Department of Surgery, Mayo Clinic, Rochester, MN, USA aut Lohse Christine Division of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN, USA aut Boughey Judy Department of Surgery, Mayo Clinic, Rochester, MN, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3174-3180 1068-9265 18:11<3174 2011 18 10434 https://doi.org/10.1245/s10434-011-1957-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1957-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ansari Bijan Department of Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Morton Marilyn Division of Breast Imaging, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Adamczyk Darcy Division of Breast Imaging, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Jones Katie Division of Breast Imaging, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Brodt Julie Department of Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Degnim Amy Department of Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Jakub James Department of Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Lohse Christine Division of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Boughey Judy Department of Surgery, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3174-3180 1068-9265 18:11<3174 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer