caa a22 4500 445339225 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1958-y doi (NATIONALLICENCE)springer-10.1245/s10434-011-1958-y Ultrasound-Guided Lumpectomy for Palpable Breast Cancers [Elektronische Daten] [Carla Fisher, Fatema Mushawah, Amy Cyr, Feng Gao, Julie Margenthaler] Background: We sought to determine the re-excision rate following lumpectomy for palpable breast cancers using intraoperative ultrasound (US). A secondary aim was to investigate the impact on surgical decision-making. Methods: We identified 73 women who underwent US-guided lumpectomy for palpable breast cancer between 2006 and 2010. A cohort of 124 women who underwent palpation-guided lumpectomy was used for a comparison group. Data included patient demographics, tumor characteristics, intraoperative findings, and pathologic outcomes. Descriptive statistics were used for data summary and compared by chi-square or t test, as appropriate. Results: A total of 73 women underwent US-guided lumpectomy, and 124 women underwent palpation-guided lumpectomy (median age 55years). Patients undergoing palpation-guided lumpectomy had smaller tumors that were more likely to be HER2/neu amplified compared with patients undergoing US-guided lumpectomy (P < 0.05 for each). There were no differences between the 2 groups with respect to patient age, tumor grade, and estrogen/progesterone receptor status (P > 0.05 for each). Re-excision rates were similar in both groups [17 (23%) in the US group versus 31 (25%) in the palpation group; P > 0.05]. In the US group, 45 patients (62%) had additional shave margins taken based on US interrogation of the specimen, and 12 patients (16%) were spared a 2nd procedure based on the use of intraoperative US. Conclusions: Although palpable breast cancers can be excised based on direct palpation or needle localization, we believe that US guidance provides an excellent tool to aid the breast surgeon. Only 10% of patients had a positive margin on final pathology as a result, and the overall re-excision rate was acceptable. Society of Surgical Oncology, 2011 Fisher Carla Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Mushawah Fatema Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Cyr Amy Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Gao Feng Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA aut Margenthaler Julie Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3198-3203 1068-9265 18:11<3198 2011 18 10434 https://doi.org/10.1245/s10434-011-1958-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1958-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fisher Carla Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Mushawah Fatema Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Cyr Amy Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Gao Feng Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Margenthaler Julie Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3198-3203 1068-9265 18:11<3198 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer