caa a22 4500 44533925X CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1920-z doi (NATIONALLICENCE)springer-10.1245/s10434-011-1920-z Triple-Negative Breast Cancer Is Not a Contraindication for Breast Conservation [Elektronische Daten] [Farrell Adkins, Ana Gonzalez-Angulo, Xiudong Lei, Leonel Hernandez-Aya, Elizabeth Mittendorf, Jennifer Litton, Jamie Wagner, Kelly Hunt, Wendy Woodward, Funda Meric-Bernstam] Background: Triple-negative breast cancer (TNBC) is an aggressive subtype shown to have a high risk of locoregional recurrence (LRR). The purpose of this study was to determine the impact of operation type on LRR in TNBC patients. Methods: A total of 1325 patients with TNBC who underwent breast-conserving therapy (BCT) or mastectomy from 1980 to the present were identified. Clinical and pathological factors were compared by the chi-square test. LRR-free survival (LRRFS), distant metastasis-free survival, and overall survival were estimated by the Kaplan-Meier method. Multivariate analysis was performed by the Cox proportional hazard models. Results: BCT was performed in 651 patients (49%) and mastectomy in 674 (51%). The mastectomy group had larger tumors, a higher incidence of lymphovascular invasion, and higher pathologic N stage (all P<0.001). At 62-month median follow-up, LRR was seen in 170 (26%) in the BCT group and 203 (30%) in the mastectomy group. Five-year LRRFS rates were higher in the BCT group (76% vs. 71%, P=0.032), as was distant metastasis-free survival (68% vs. 54%, P<0.0001) and overall survival (74% vs. 63%, P<0.0001). On multivariate analysis, T stage (hazard ratio [HR] 1.37, P=0.006), high nuclear grade (HR 1.92, P=0.002), lymphovascular invasion (HR 1.93, P<0.0001), close/positive margins (HR 1.89, P<0.0001), and use of non-anthracycline or taxane-based adjuvant chemotherapy (HR 2.01, P<0.0001) increased the LRR risk, while age >50years was protective (HR 0.73, P=0.007). Operation type (mastectomy vs. BCT, HR 1.07, P=0.55) was not statistically significant. Conclusions: BCT is not associated with increased LRR rates compared to mastectomy. TNBC should not be considered a contraindication for breast conservation. Society of Surgical Oncology, 2011 Adkins Farrell Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Gonzalez-Angulo Ana Department Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Lei Xiudong Department of Biostatistics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Hernandez-Aya Leonel Department Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Mittendorf Elizabeth Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Litton Jennifer Department Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Wagner Jamie Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Hunt Kelly Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Woodward Wendy Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Meric-Bernstam Funda Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3164-3173 1068-9265 18:11<3164 2011 18 10434 https://doi.org/10.1245/s10434-011-1920-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1920-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Adkins Farrell Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Gonzalez-Angulo Ana Department Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Lei Xiudong Department of Biostatistics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Hernandez-Aya Leonel Department Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Mittendorf Elizabeth Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Litton Jennifer Department Breast Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Wagner Jamie Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Hunt Kelly Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Woodward Wendy Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Meric-Bernstam Funda Department of Surgical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3164-3173 1068-9265 18:11<3164 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer