caa a22 4500 445339306 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1910-1 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1910-1 Radioactive Seed Localization for Nonpalpable Breast Lesions: Review of 1,000 Consecutive Procedures at a Single Institution [Elektronische Daten] [Lee McGhan, Sara McKeever, Barbara Pockaj, Nabil Wasif, Marina Giurescu, Heidi Walton, Richard Gray] Introduction: Radioactive seed localization (RSL) is an alternative to wire localization for nonpalpable breast lesions, with reported lower rates of positive surgical margins. Methods: A retrospective review of all consecutive RSL procedures performed at a single institution from 01/2003 through 10/2010 was conducted. Results: One thousand RSL breast procedures were performed in 978 patients. Indications for RSL included invasive carcinoma (52%), in situ carcinoma (22%), atypical hyperplasia (11%), and suspicious percutaneous biopsy findings (15%). A total of 1,148 seeds were deployed using image guidance, with 76% placed ≥1day before surgery. Most procedures (86%) utilized one seed. A negative margin was achieved at the first operation in 97% of patients with invasive carcinoma and 97% of patients with ductal carcinoma in situ (DCIS). An additional 9% of patients with invasive carcinoma and 19% of patients with DCIS had close (≤2mm) margins, and underwent re-excision. Sentinel lymph node biopsy was successfully performed in 99.8% of cases. Adverse events included 3 seeds (0.3%) not deployed correctly on first attempt and 30 seeds (2.6%) displaced from the breast specimen during excision of the targeted lesion. All seeds were successfully retrieved, with no radiation safety concerns. Local recurrence rates were 0.9% for invasive breast cancer and 3% for DCIS after mean follow-up of 33months. There was no evidence of a learning curve. Conclusions: RSL is a safe, effective procedure that is easy to learn, with a low incidence of positive/close margins. RSL should be considered as the method of choice for localization of nonpalpable breast lesions. Society of Surgical Oncology, 2011 McGhan Lee Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut McKeever Sara Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut Pockaj Barbara Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut Wasif Nabil Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut Giurescu Marina Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut Walton Heidi Radiation Safety Office, Mayo Clinic, Scottsdale, AZ, USA aut Gray Richard Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3096-3101 1068-9265 18:11<3096 2011 18 10434 https://doi.org/10.1245/s10434-011-1910-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1910-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGhan Lee Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut NATIONALLICENCE 700 1- McKeever Sara Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut NATIONALLICENCE 700 1- Pockaj Barbara Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut NATIONALLICENCE 700 1- Wasif Nabil Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut NATIONALLICENCE 700 1- Giurescu Marina Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Walton Heidi Radiation Safety Office, Mayo Clinic, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Gray Richard Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, Arizona, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3096-3101 1068-9265 18:11<3096 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer