caa a22 4500 445339330 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1915-9 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1915-9 Potential Impact of USPSTF Recommendations on Early Diagnosis of Breast Cancer [Elektronische Daten] [Robert Aragon, John Morgan, Jan Wong, Sharon Lum] Objective: Current US Preventive Services Task Force (USPSTF) guidelines recommend against routine screening mammography in women aged 40-49years. However, diagnosis of early-stage breast cancer relies on mammographic screening for detection. We hypothesized that screening at younger age may be important for detecting earlier and more treatable cancers for women in different demographic groups. Methods: All women with ductal carcinoma in situ (DCIS) or T1N0 breast cancer between 2004 and 2008 in the California Cancer Registry were evaluated. Patients were divided into: (1) women aged 40-49years, who would be excluded from USPSTF recommendations for screening, and (2) women aged 50-74years, who are recommended for screening. Patients in the two age groups were compared by race/ethnicity, socioeconomic status (SES), and hormone receptor (HR), human epidermal growth factor receptor 2 (HER-2), and triple-negative (TN) status. Results: Of 46,691 patients identified, 22.6% were aged 40-49years, and 77.4% were aged 50-74years. Younger women with DCIS had statistically higher odds of being HR positive and having higher SES, and Hispanic and Asian/Pacific Islander (PI) race/ethnicity, while younger women diagnosed with T1N0 breast cancer had higher odds of being HR positive, HER-2 positive, and triple negative and of having higher SES and non-white race/ethnicity. Conclusions: Young Hispanic, Asian/PI, and non-Hispanic (NH) Black women in California have greater odds of being diagnosed with early breast cancer than their older counterparts. Excluding 40-49-year-old women from screening could impact early diagnosis of HR-positive, HER-2-positive, and TN tumors. Implementation of USPSTF recommendations could disproportionately impact non-white women and potentially lead to more advanced presentation at diagnosis. Society of Surgical Oncology, 2011 Aragon Robert Department of Surgery, Division of Surgical Oncology, Loma Linda University School of Medicine, Loma Linda, CA, USA aut Morgan John School of Public Health, Loma Linda University, Loma Linda, CA, USA aut Wong Jan Department of Surgery, Division of Surgical Oncology, Brody School of Medicine, East Carolina University, Greenville, NC, USA aut Lum Sharon Department of Surgery, Division of Surgical Oncology, Loma Linda University School of Medicine, Loma Linda, CA, USA aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3137-3142 1068-9265 18:11<3137 2011 18 10434 https://doi.org/10.1245/s10434-011-1915-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1915-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aragon Robert Department of Surgery, Division of Surgical Oncology, Loma Linda University School of Medicine, Loma Linda, CA, USA aut NATIONALLICENCE 700 1- Morgan John School of Public Health, Loma Linda University, Loma Linda, CA, USA aut NATIONALLICENCE 700 1- Wong Jan Department of Surgery, Division of Surgical Oncology, Brody School of Medicine, East Carolina University, Greenville, NC, USA aut NATIONALLICENCE 700 1- Lum Sharon Department of Surgery, Division of Surgical Oncology, Loma Linda University School of Medicine, Loma Linda, CA, USA aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3137-3142 1068-9265 18:11<3137 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer