caa a22 4500 445339357 CHVBK 20180317142806.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1245/s10434-011-1960-4 doi (NATIONALLICENCE)springer-10.1245/s10434-011-1960-4 Breast Cancer in Hong Kong, Southern China: The First Population-Based Analysis of Epidemiological Characteristics, Stage-Specific, Cancer-Specific, and Disease-Free Survival in Breast Cancer Patients: 1997-2001 [Elektronische Daten] [Ava Kwong, Oscar Mang, Connie Wong, W. Chau, Stephen Law] Background: Cancer registries have been set up worldwide to provide information for cancer health planning. There are known variations in breast cancer incidence and mortality worldwide. However, breast cancer incidence, pathological characteristics, and survival data is still under-reported in Asian countries. This is the first comprehensive population-based breast cancer study performed using population database of the Hong Kong Cancer Registry. Methods: A retrospective review of medical records of 8,961 subjects who were diagnosed with breast cancer between January 1, 1997 to December 31, 2001 and followed up to December 31, 2007. Descriptive statistics were employed to analyze the epidemiological and clinical data. Estimates of overall, disease-free, and cancer-specific survival at 5years were estimated by the Kaplan-Meier method and stage-specific relative survival rates were calculated. Results: A total of 7,630 breast cancer patients' medical records and dataset were available during this period, and 7,449 subjects were eligible for the final analysis. Median follow-up was 84months. A total of 47.4% were diagnosed with breast cancer at age 49years and younger; 22.2%, 46.9%, 10.8%, and 4.1% presented at stages I, II, III, and IV, respectively. A total of 53.5% had ER-positive cancer, and 20.3% had HER2-positive cancers; 13.4% had triple-negative cancers. The relative, cancer-specific, and disease-free survival rates at 5years were 84%, 85.2%, and 81.2%, respectively. Discussion: We performed the first comprehensive population-based breast cancer epidemiology study in Southern China using the Hong Kong Cancer Registry database. This provides a baseline study cohort for comparative studies with other Asian countries and Chinese who have migrated to the West. The Author(s), 2011 Kwong Ava Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China aut Mang Oscar The Hong Kong Cancer Registry, Hospital Authority, Hong Kong, China aut Wong Connie Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China aut Chau W. Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China aut Law Stephen The Hong Kong Cancer Registry, Hospital Authority, Hong Kong, China aut Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3072-3078 1068-9265 18:11<3072 2011 18 10434 https://doi.org/10.1245/s10434-011-1960-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1245/s10434-011-1960-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kwong Ava Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Mang Oscar The Hong Kong Cancer Registry, Hospital Authority, Hong Kong, China aut NATIONALLICENCE 700 1- Wong Connie Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Chau W. Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Law Stephen The Hong Kong Cancer Registry, Hospital Authority, Hong Kong, China aut NATIONALLICENCE 773 0- Annals of Surgical Oncology Springer-Verlag 18/11(2011-10-01), 3072-3078 1068-9265 18:11<3072 2011 18 10434 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer