caa a22 4500 445339411 CHVBK 20180317142807.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00436-010-2219-x doi (NATIONALLICENCE)springer-10.1007/s00436-010-2219-x Seaweeds as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India [Elektronische Daten] [Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi] The problems of resistant lines of Plasmodium falciparum are escalating. Twelve seaweeds species belong to five different families (Sargassaceae, Gracilariaceae, Hypneaceae, Corallinaceae and Halimedaceae) were collected from Mandapam coastal area, and the seaweeds extracts were tested for in vitro antiplasmodial activity against P. falciparum. Among the tested seaweeds, Gracilaria verrucosa (IC50 5.55 μg.ml−1) and Hypnea espera (IC50 8.94 μg.ml−1) showed good antiplasmodial activity, and these results are comparable with positive controls such as artemether (IC50 4.09 μg.ml−1) and chloroquine (IC50 19.59 μg.ml−1), respectively. Turbinaria conoides, Sargassum myriocystem, Hypnea valentiae and Jania rubens extracts showed IC50 values between 5 to 50 μg.ml−1. Sargassum sp., Turbinaria decurrens and Halimeda gracilis extracts showed IC50 values between 50 to 100 μg.ml−1. Gracilaria corticata, Jania adherens and Halimeda opuntia extracts showed IC50 value of more than 100 μg.ml−1. Statistical analysis reveals that significant in vitro antiplasmodial activity (P < 0.05) was observed between the concentrations and time of exposure. The chemical injury to erythrocytes was also carried out, and it shows that no morphological changes in erythrocytes by the ethanolic extract of seaweeds extracts after 48h of incubation. The in vitro antiplasmodial activity might be due to the presence of sugars, proteins, phenols and carboxylic acid in the ethanolic extracts of seaweeds. It is concluded from the present study that the ethanolic extracts of seaweeds of G. verrucosa and Hypnea espera possess lead compounds for development of antiplasmodial drugs. Springer-Verlag, 2010 Ravikumar Sundaram School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, 623 409, Thondi, Ramanathapuram District, Tamil Nadu, India aut Jacob Inbaneson Samuel School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, 623 409, Thondi, Ramanathapuram District, Tamil Nadu, India aut Suganthi Palavesam School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, 623 409, Thondi, Ramanathapuram District, Tamil Nadu, India aut Parasitology Research Springer-Verlag 109/1(2011-07-01), 47-52 0932-0113 109:1<47 2011 109 436 https://doi.org/10.1007/s00436-010-2219-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2219-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ravikumar Sundaram School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, 623 409, Thondi, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Jacob Inbaneson Samuel School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, 623 409, Thondi, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Suganthi Palavesam School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, 623 409, Thondi, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/1(2011-07-01), 47-52 0932-0113 109:1<47 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer