caa a22 4500 44533956X CHVBK 20180317142807.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00436-010-2216-0 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2216-0 Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep [Elektronische Daten] [Ronald Kaminsky, Beatrice Bapst, Philip Stein, Guenther Strehlau, Brooke Allan, Barry Hosking, Peter Rolfe, Heinz Sager] Drug resistance has become a global phenomenon in gastrointestinal nematodes of sheep, particularly resistance to macrocyclic lactones. New anthelmintics are urgently needed for both the control of infections with multi-resistant nematodes in areas where classical anthelmintics are no longer effective, and the prevention of the spread of resistance in areas where the problem is not as severe. Recently, two new active ingredients became commercially available for the treatment of nematode infections in sheep, monepantel (Zolvix®) and derquantel, the latter used only in a formulated combination with the macrocyclic lactone, abamectin (Startect®). In order to assess the potential of the new actives for the control and prevention of spread of anthelmintic resistance, two characterized multi-resistant field isolates from Australia were used in a GLP (good laboratory practice) conducted efficacy study in sheep. Eight infected sheep in each group were treated orally according to the product labels with 2.5mg/kg body weight monepantel, 0.2mg/kg abamectin, or with the combination of 2.0mg/kg derquantel and 0.2mg/kg abamectin. The results demonstrate that monepantel was fully effective against multi-resistant species, Trichostrongylus colubriformis and Haemonchus contortus (99.9%). In contrast, the combination of derquantel and abamectin was effective against T. colubriformis (99.9%), but was not effective against larval stages of the barber's pole worm H. contortus (18.3%). The Author(s), 2010 Kaminsky Ronald Novartis Centre de Recherche Santé Animale, CH-1566 St. Aubin, Switzerland aut Bapst Beatrice Novartis Centre de Recherche Santé Animale, CH-1566 St. Aubin, Switzerland aut Stein Philip Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut Strehlau Guenther Novartis Animal Health Inc., CH-4058, Basel, Switzerland aut Allan Brooke Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut Hosking Barry Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut Rolfe Peter Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut Sager Heinz Novartis Centre de Recherche Santé Animale, CH-1566 St. Aubin, Switzerland aut Parasitology Research Springer-Verlag 109/1(2011-07-01), 19-23 0932-0113 109:1<19 2011 109 436 https://doi.org/10.1007/s00436-010-2216-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2216-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaminsky Ronald Novartis Centre de Recherche Santé Animale, CH-1566 St. Aubin, Switzerland aut NATIONALLICENCE 700 1- Bapst Beatrice Novartis Centre de Recherche Santé Animale, CH-1566 St. Aubin, Switzerland aut NATIONALLICENCE 700 1- Stein Philip Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Strehlau Guenther Novartis Animal Health Inc., CH-4058, Basel, Switzerland aut NATIONALLICENCE 700 1- Allan Brooke Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Hosking Barry Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Rolfe Peter Novartis Animal Health Australasia Pty Limited, Yarrandoo R & D Centre, 245 Western Road, Kemps Creek, 2178, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Sager Heinz Novartis Centre de Recherche Santé Animale, CH-1566 St. Aubin, Switzerland aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/1(2011-07-01), 19-23 0932-0113 109:1<19 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer