caa a22 4500 44533987X CHVBK 20180317142808.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00436-011-2438-9 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2438-9 Efficacy of sulfonamides and Baycox® against Isospora suis in experimental infections of suckling piglets [Elektronische Daten] [Anja Joachim, Hans-Christian Mundt] Sulfonamide treatment of piglets against neonatal coccidiosis has frequently been suggested in the literature. In order to evaluate the efficacy of sulfonamides against experimental Isospora suis infections in suckling piglets (oral infection with 1,500 sporulated oocysts of I. suis per piglet on the fourth day of life), two trials were conducted. In trial I, oral sulfadimidine (group Sulfa-Oral) was applied in doses of 100mg/kg of body weight (BW) 1day before infection and 75mg/kg BW daily for the following 5days, and sulfamethoxypyrimidine (SMP) was applied parenterally in daily doses of 75mg/kg BW for the same time period. In trial II, SMP was applied parenterally in doses of 75mg/kg BW (a) from the day of infection daily for 7days (SMP-Standard), (b) for 2days starting on the day of infection (SMP-Early), (c) for 3days starting 2days post-infection (d.p.i.; SMP-Middle), (d) for 2days starting 5d.p.i. (SMP-Late), and (e) every other day from the day of infection until 6d.p.i. (SMP-Alternating), as well as (f) orally in doses of 75mg/kg BW from the day of infection for 7days (SMP-Oral). The sulfonamide-treated groups were compared to a toltrazuril-treated group (single oral treatment with Baycox® 5% suspension, 20mg/kg BW 2d.p.i.) and to a water-treated Control group. Each group consisted of seven to nine piglets. The parameters evaluated were oocyst excretion and fecal consistency/diarrhea from 4 to 15d.p.i. Sulfa-Oral, SMP-Early, and SMP-Late had no significant effect in reduction of oocyst excretion and diarrhea, whereas treatment for 3-7days with SMP reduced both parasite shedding and diarrhea significantly. Oral treatment with SMP was comparable to parenteral application. Baycox® in a single application had the most pronounced effect and completely suppressed oocyst excretion and diarrhea during the examination period. It could be shown that repeated application of sulfonamides, provided that the appropriate time period after infection is covered, can in principle be used to control piglet coccidiosis; however, the amount of work required is considerable, and the practicability is poor. Due to the short half-life of sulfonamides in pigs and the lack of predictability of the time point of infection, an efficient application of sulfonamides to control piglet coccidiosis under field conditions appears unlikely. Baycox®, on the other hand, applied once during the prepatent period of infection, had a lasting effect and can be used to most effectively control I. suis. Springer-Verlag, 2011 Joachim Anja Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria aut Mundt Hans-Christian Bayer Animal Health GmbH, Clinical R & D Parasiticides, 51368, Leverkusen, Germany aut Parasitology Research Springer-Verlag 109/6(2011-12-01), 1653-1659 0932-0113 109:6<1653 2011 109 436 https://doi.org/10.1007/s00436-011-2438-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2438-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Joachim Anja Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria aut NATIONALLICENCE 700 1- Mundt Hans-Christian Bayer Animal Health GmbH, Clinical R & D Parasiticides, 51368, Leverkusen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/6(2011-12-01), 1653-1659 0932-0113 109:6<1653 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer