caa a22 4500 445339969 CHVBK 20180317142809.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00436-011-2413-5 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2413-5 Genetic diversity of the malaria vaccine candidate merozoite surface protein 1 gene of Plasmodium vivax field isolates in Republic of Korea [Elektronische Daten] [Eun-Taek Han, Yue Wang, Chae Lim, Jun Cho, Jong-Yil Chai] The Plasmodium vivax merozoite surface protein 1 (Pvmsp-1) locus codes for a major asexual blood-stage antigen currently proposed as a malaria vaccine candidate antigen. However, extensive polymorphism of this protein has been observed in isolates from different geographical areas. Here, we investigate the extent and the frequency of allelic diversity at the Pvmsp-1 locus in field isolates collected in the Republic of Korea during the past decade. Among the 45 Korean isolates, six Pvmsp-1 gene types (SKOR-I to SKOR-VI) were identified as unique combinations of type sequences in each variable block. Of these six different Pvmsp-1 gene types, two major Pvmsp-1 allelic types were found in 72% (SKOR-I) and 28% (SKOR-II) of field isolates collected in 1996 to 2000, and four different allelic types (SKOR-III to SKOR-VI) emerged in 70% (10-25%) of isolates collected in 2007 to 2009. These results suggest that allelic diversity of Pvmsp-1 increased in several variable regions, including the N- and C-terminals, after reemergence of P. vivax parasites in the Republic of Korea. Springer-Verlag, 2011 Han Eun-Taek Department of Parasitology, Kangwon National University School of Medicine, Hyoja2-dong, 200-701, Chuncheon, Gangwon-do, Republic of Korea aut Wang Yue Department of Parasitology, Kangwon National University School of Medicine, Hyoja2-dong, 200-701, Chuncheon, Gangwon-do, Republic of Korea aut Lim Chae Department of Laboratory Medicine, College of Medicine, Korea University, 152-703, Seoul, Republic of Korea aut Cho Jun Institute of Medical Science, Kangwon National University School of Medicine, Hyoja2-dong, 200-701, Chuncheon, Gangwon-do, Republic of Korea aut Chai Jong-Yil Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, 110-799, Seoul, Republic of Korea aut Parasitology Research Springer-Verlag 109/6(2011-12-01), 1571-1576 0932-0113 109:6<1571 2011 109 436 https://doi.org/10.1007/s00436-011-2413-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2413-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Han Eun-Taek Department of Parasitology, Kangwon National University School of Medicine, Hyoja2-dong, 200-701, Chuncheon, Gangwon-do, Republic of Korea aut NATIONALLICENCE 700 1- Wang Yue Department of Parasitology, Kangwon National University School of Medicine, Hyoja2-dong, 200-701, Chuncheon, Gangwon-do, Republic of Korea aut NATIONALLICENCE 700 1- Lim Chae Department of Laboratory Medicine, College of Medicine, Korea University, 152-703, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Cho Jun Institute of Medical Science, Kangwon National University School of Medicine, Hyoja2-dong, 200-701, Chuncheon, Gangwon-do, Republic of Korea aut NATIONALLICENCE 700 1- Chai Jong-Yil Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, 110-799, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/6(2011-12-01), 1571-1576 0932-0113 109:6<1571 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer