caa a22 4500 445340207 CHVBK 20180317142810.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00436-011-2299-2 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2299-2 Transmission dynamics of two strains of Schistosoma mansoni utilizing novel intermediate and definitive hosts [Elektronische Daten] [Omari Jones-Nelson, Elizabeth Thiele, Dennis Minchella] The intimate host-parasite relationship mandates adaptation to the genetic and phenotypic variability of their counterparts. Here, inbred and outcrossed strains of Schistosoma mansoni were challenged with "local” and "novel” intermediate and definitive hosts to examine effects of genetic variability and novelty on infection success and dynamics. Genetically distinct lines of Biomphalaria glabrata intermediate hosts exposed to inbred and outcrossed S. mansoni larvae were assessed for differences in both snail and parasite life-history parameters. Cercariae from each parasite-snail treatment were used to infect "local” and "novel” Mus musculus definitive hosts to assess parasite infectivity and fitness. Outcrossed parasites significantly reduced snail growth, were more productive, and induced greater host mortality than inbred parasites. Mouse strain did not influence parasite infectivity or reproduction, but parasite and snail host genetic background did, affecting both sex-specific infectivity and parasite productivity. Overall, genetic background of S. mansoni and its intermediate snail host altered life history traits and transmission dynamics of the parasite throughout its life cycle. Springer-Verlag, 2011 Jones-Nelson Omari Department of Biological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut Thiele Elizabeth Department of Biological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut Minchella Dennis Department of Biological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut Parasitology Research Springer-Verlag 109/3(2011-09-01), 675-687 0932-0113 109:3<675 2011 109 436 https://doi.org/10.1007/s00436-011-2299-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2299-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jones-Nelson Omari Department of Biological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut NATIONALLICENCE 700 1- Thiele Elizabeth Department of Biological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut NATIONALLICENCE 700 1- Minchella Dennis Department of Biological Sciences, Purdue University, 47907, West Lafayette, IN, USA aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/3(2011-09-01), 675-687 0932-0113 109:3<675 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer