caa a22 4500 445340363 CHVBK 20180317142810.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00436-011-2282-y doi (NATIONALLICENCE)springer-10.1007/s00436-011-2282-y Opisthorchis viverrini infection causes liver and biliary cirrhosis in gerbils [Elektronische Daten] [Orasa Wonkchalee, Thidarut Boonmars, Sasithron Kaewkes, Yaovaluk Chamgramol, Chawalit Pairojkul, Zhiliang Wu, Amornrat Juasook, Pakkayanee Sudsarn, Sirintip Boonjaraspinyo] Opisthorchis viverrini infection causes many hepatobiliary diseases, including cholangiocarcinoma. Hence, the study of O. viverrini infection in humans is subject to ethical limitations, so an animal model, the Syrian hamster, is often used. O. viverrini can develop into the adult stage not only in Syrian hamsters but also in other animals, including gerbils, but until now, there has been no report on pathology and susceptibility in gerbils. The present study revealed the pathology of O. viverrini infection in gerbils through gross appearance, histopathology, and worm recovery at various time points. Gerbils were infected with 50 O. viverrini metacercariae and then sacrificed at the time of observation. The gross appearance of the liver showed micronodules at the liver surface, suggesting liver and biliary cirrhosis. Light microscopic observation was correlated to the gross appearance with cholecystitis, fatty liver changes, fibrous septa, and generalized cirrhosis. The range of worm burden fluctuated from 1 to 25 worms with large body size, which was correlated with pathology. These novel findings indicate that O. viverrini infection can cause liver and biliary cirrhosis in gerbils, depending on the worm burden, worm size, and habitat. Springer-Verlag, 2011 Wonkchalee Orasa Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Boonmars Thidarut Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Kaewkes Sasithron Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Chamgramol Yaovaluk Department of Pathology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Pairojkul Chawalit Department of Pathology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Wu Zhiliang Department of Parasitology, Gifu University Graduate School of Medicine, Yanagido1-1, 501-1194, Gifu, Japan aut Juasook Amornrat Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Sudsarn Pakkayanee Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Boonjaraspinyo Sirintip Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut Parasitology Research Springer-Verlag 109/3(2011-09-01), 545-551 0932-0113 109:3<545 2011 109 436 https://doi.org/10.1007/s00436-011-2282-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2282-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wonkchalee Orasa Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Boonmars Thidarut Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Kaewkes Sasithron Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Chamgramol Yaovaluk Department of Pathology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Pairojkul Chawalit Department of Pathology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Wu Zhiliang Department of Parasitology, Gifu University Graduate School of Medicine, Yanagido1-1, 501-1194, Gifu, Japan aut NATIONALLICENCE 700 1- Juasook Amornrat Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Sudsarn Pakkayanee Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 700 1- Boonjaraspinyo Sirintip Department of Parasitology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/3(2011-09-01), 545-551 0932-0113 109:3<545 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer