caa a22 4500 44534038X CHVBK 20180317142810.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00436-011-2324-5 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2324-5 Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin [Elektronische Daten] [Rubens Rodriguez, Sérgio Porto, Rodrigo dos Santos Ferrari, Ana Marcolan, Ana da Silva, Carlos Graeff-Teixeira, Fernando Fornari] Abdominal angiostrongyliasis (AA) is caused by the nematode Angiostrongylus costaricensis. Parasite-associated thrombosis of mesenteric vessels may lead to intestinal infarction, which might be prevented with anti-thrombotic agents. This study assessed the effect of enoxaparin on survival and pathological findings in Swiss mice with AA. In this experiment, 24 mice were infected with A. costaricensis (10 L3 per animal) followed by treatment with subcutaneous enoxaparin (40mg/kg/day) or water (sham), starting from 15days post-infection (dpi) and continued until animal death. Animals were monitored until death or sacrifice at the 50th dpi. Ten mice (42%) were dead after 36 ± 8dpi. Of these, five (50%) were treated with enoxaparin. Animals treated with enoxaparin and sham did not differ in terms of weight loss (median, 1.3 vs. 4.2g; P = 0.303) and macroscopical findings. Microscopically, no difference was found in regard to vascular granuloma (median grade, 2 vs. 3; P = 0.293) and presence of either vasculitis (75% vs. 100%; P = 0.217), mesenteric thrombosis (33% vs. 50%; P = 0.680), or bowel necrosis (25% vs. 50%; P = 0.400). Mice dead before the 50th dpi showed more pneumonia (90% vs. 21%; P = 0.002), bowel infarction (40% vs. 0%; P = 0.02), and purulent peritonitis (60% vs. 7%; P = 0.008) compared to survivors. Prophylactic enoxaparin in mice did not prevent tissue damage and mortality related with AA. The lower prevalence of mesenteric thrombosis and bowel infarction regardless of treatment were notorious. Frequent septic complications suggest the need of studies addressing the effect of antibiotics in AA. Springer-Verlag, 2011 Rodriguez Rubens Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, no 2400, 2º andar, CEP 90035-003, Porto Alegre, RS, Brazil aut Porto Sérgio Instituto de Ciências Biológicas, UPF, Passo Fundo, RS, Brazil aut dos Santos Ferrari Rodrigo Faculdade de Medicina, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brazil aut Marcolan Ana Faculdade de Medicina, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brazil aut da Silva Ana Laboratório de Biologia Parasitária, Faculdade de Biociências da PUCRS, Porto Alegre, RS, Brazil aut Graeff-Teixeira Carlos Laboratório de Biologia Parasitária, Faculdade de Biociências da PUCRS, Porto Alegre, RS, Brazil aut Fornari Fernando Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, no 2400, 2º andar, CEP 90035-003, Porto Alegre, RS, Brazil aut Parasitology Research Springer-Verlag 109/3(2011-09-01), 787-792 0932-0113 109:3<787 2011 109 436 https://doi.org/10.1007/s00436-011-2324-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2324-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rodriguez Rubens Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, no 2400, 2º andar, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Porto Sérgio Instituto de Ciências Biológicas, UPF, Passo Fundo, RS, Brazil aut NATIONALLICENCE 700 1- dos Santos Ferrari Rodrigo Faculdade de Medicina, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brazil aut NATIONALLICENCE 700 1- Marcolan Ana Faculdade de Medicina, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brazil aut NATIONALLICENCE 700 1- da Silva Ana Laboratório de Biologia Parasitária, Faculdade de Biociências da PUCRS, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Graeff-Teixeira Carlos Laboratório de Biologia Parasitária, Faculdade de Biociências da PUCRS, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Fornari Fernando Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, no 2400, 2º andar, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/3(2011-09-01), 787-792 0932-0113 109:3<787 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer